Treatment of cancers by inhalation of stable platinum-containing formulations

a technology of stable platinum and cancer, which is applied in the direction of drug composition, dispersed delivery, peptide/protein ingredients, etc., can solve the problems of cisplatin's association with several adverse side effects, nausea and vomiting, and hearing loss, and achieve the effect of preventing the degradation of cisplatin

Inactive Publication Date: 2005-05-19
PILKIEWICZ FR G +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009] A stable platinum-based formulation can be produced by milling a platinum-based drug, such as cisplatin, to a powder and combining it with sodium chloride as a dry powder blend suitable for administration by inhalation. The resulting formulation can include one or more phospholipids or liposomes. The presence of extraneous chloride ions are known to prevent the cisplatin from degrading by l

Problems solved by technology

Cisplatin converts to an ineffective form in aqueous solution, consequently, cisplatin solutions must be stabilized or the drug will lose its anti-tumor effectiveness.
Cisplatin is associated with several adverse side effects, including nausea and vomiting, kidney damage, and hearing loss.
With this local application approach, inhalation can reduce the side effects of cisplatin and other platinum-containing agents normally encountered after intravenous administration, due to limited bioavailability to tissues and organs via the bl

Method used

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Embodiment Construction

[0021] The present invention is related to methods of treating cancers involving inhalation of a platinum-containing formulation. The platinum-containing formulation is inhaled into the subject's respiratory tract, where it is targeted to cancerous lesions found in the lungs or airways. It will be cleared from the lungs via cellular uptake and transferred to the lymphatic system where it may affect other cancers.

[0022] The primary advantages of the present invention over the prior art involve the benefits of inhalation therapy over injection or infusion. Previously, formulations of cisplatin were not adequately stabilized to allow administration by inhalation. Using the stabilization methods of the present invention, however, administration by inhalation is now available.

[0023] Inhalation is preferable to injection or infusion for three main reasons. First, it allows for localized administration of the antineoplastic agent to tumors of the bronchial pathways, lungs, and surroundin...

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Abstract

Disclosed are methods of treating cancers by inhalation of stable platinum-containing formulations.

Description

[0001] This Application claims benefit to a provisional application No. 60 / 313,528 filed on Aug. 20, 2001.[0002] The present invention relates to methods of treating cancers by administering stable platinum-containing formulations by inhalation into a subject's respiratory tract. More particularly, the present invention relates to methods of administration of cisplatin compounds by inhalation to treat lung cancers. [0003] Cisplatin has been used for the treatment of cancers since the 1970's. It is an antineoplastic, inhibiting cell division. Cisplatin has been particularly useful in treating testicular and ovarian cancers, with good results also shown for cancers of the head and neck, esophagus, bladder, and lung. Cisplatin converts to an ineffective form in aqueous solution, consequently, cisplatin solutions must be stabilized or the drug will lose its anti-tumor effectiveness. Cisplatin is associated with several adverse side effects, including nausea and vomiting, kidney damage, ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/127A61K31/282A61K31/555A61K33/243A61K38/40A61K45/06
CPCA61K9/0075Y10S514/908A61K9/127A61K9/1277A61K31/282A61K31/555A61K33/24A61K38/40A61K45/06A61K9/008A61K2300/00A61P35/00A61K33/243
Inventor PILKIEWICZ, FRANK G.PORTNOFF, JOEL B.BONI, LAWRENCE T.LEE, JIN K.
Owner PILKIEWICZ FR G
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