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Method and apparatus for monitoring of proteins and cells

a technology for proteins and cells, applied in the field of protein and cell analysis, can solve the problem of losing the return on any investment in discovery efforts

Inactive Publication Date: 2005-06-23
BAHNSON ALFRED BLALOCK +5
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0018] The present invention pertains to an apparatus for monitoring the effects of proteins and other biological and chemical moieties on cells. The apparatus comprises a plate having wells in which cells are disposed. The apparatus comprises means for causing each cell to move to a corner of each well. The causing means is connected to the plate.
[0019] The present invention pertains to a method for monitoring the effects of proteins and other biological and chemical moieties on a cell. The method comprises the steps of loading one cell in each well of a plurality of wells of a plate. There is the step of causing each cell to move to a corner of each well.

Problems solved by technology

The return on any investment in discovery efforts can be lost when a particularly promising candidate has a weak functional role in a disease-relevant system.

Method used

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Embodiment Construction

[0038] Referring now to the drawings wherein like reference numerals refer to similar or identical parts throughout the several views, and more specifically to FIG. 3a thereof, there is shown an apparatus for manipulating cells. The apparatus comprises a plate having wells which hold cells. The apparatus comprises a controller. The apparatus comprises a pipette means for aspirating a well and controlled by the controller which guides the pipette means to a predetermined position in a well of the plate having a predetermined cell to aspirate the cell with the pipette from the well and place it at another location.

[0039] The present invention pertains to a method for analyzing the effects of a protein or other biological or chemical moiety on a single cell or a population or subpopulation of cells. The method comprises the steps of placing the cell(s) in a solution. There is the step of using time lapse imaging to analyze motility and other morphological phenotypical parameters of th...

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Abstract

An apparatus for monitoring proteins and cells. The apparatus includes a plate having wells in which cells are disposed. The apparatus includes means for analyzing the effect or proteins and other biological and chemical moieties on the cells. A method for monitoring of proteins and cells. A method for analyzing a cells. An apparatus for aligning light in a well of a plate for holding cells. A method for lighting a well. A method for determining a condition of a cell. An apparatus for indicating a condition of a cell. A method for establishing a focus profile of a plate having wells for holding cells. A method for manipulating cells. An apparatus for manipulating cells.

Description

FIELD OF THE INVENTION [0001] The present invention is related to the analysis and study of proteins and cells. More specifically, the present invention is related to the analysis and study of the effects of proteins and other biological and chemical moieties on cells in wells of a plate where the environment of the cells is manipulated and techniques facilitate the identification and tracking of the individual cells and population of cells in the wells. BACKGROUND OF THE INVENTION [0002] The analysis of the effects of proteins and other biological and chemical moieties on cells is an important field for the development of improved therapeutics for human health. The analysis of human and other types of cells requires sophisticated analysis methods. This patent application is directed at the improvement of the protein and cellular analysis methods used for drug discovery and gene and protein function determination. [0003] Establishing protein function is a key part of any drug discov...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B01L7/02B01L9/00C12Q1/24G01N15/14
CPCB01L7/02B01L9/00C12Q1/24G01N15/1475Y10T436/101666G01N2015/1443G01N2015/1479G01N2015/1497G01N2035/00574G01N35/10G01N15/1433
Inventor BAHNSON, ALFRED BLALOCKKOEBLER, DOUGLAS J.ATHANASSIOU, CHARALAMBOS N.HOUCK, RAYMOND K.SACHSENMEIER, KRIS F.QIAN, LEI
Owner BAHNSON ALFRED BLALOCK
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