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Antibodies that specifically bind to FDF03

a technology of fdf03 and antibodies, applied in the field of antibodies that specifically bind to fdf03, can solve the problems of lack of knowledge about the structural, biological and physiological properties of these cells, and the inability to fully understand the processes and mechanisms of initiation of an immune response, including antigen processing and presentation, and the lack of characterization of monocytes

Inactive Publication Date: 2005-12-29
SCHERING CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0017] Other nucleic acids include those which: hybridize under wash conditions of 30° C. and less than 2M salt to the coding portions of SEQ ID NO: 1 or 3; hybridize under wash conditions of 30° C. and less than 2 M salt to the coding portions of SEQ ID NO: 5, 7, or 9; hybridize under wash conditions of 30° C. and less than 2M salt to the coding portions of SEQ ID NO: 11, 13, 15, 17, 19, or 21; exhibit at least about 85% identity over a stretch of at least about 30 nucleotides to a prim

Problems solved by technology

However, monocytes are poorly characterized, both in terms of proteins they express, and many of their functions and mechanisms of action, including their activated states.
In particular, the processes and mechanisms related to the initiation of an immune response, including antigen processing and presentation, remain unclear.
The absence of knowledge about the structural, biological, and physiological properties of these cells limits their understanding.
Thus, medical conditions where regulation, development, or physiology of antigen presenting cells is unusual remain unmanageable.

Method used

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examples

I. General Methods

[0161] Many of the standard methods below are described or referenced, e.g., in Maniatis, et al. (1982) Molecular Cloning, A Laboratory Manual Cold Spring Harbor Laboratory, Cold Spring Harbor Press, NY; Sambrook, et al. (1989) Molecular Cloning: A Laboratory Manual (2d ed.) Vols. 1-3, CSH Press, NY; Ausubel, et al., Biology Greene Publishing Associates, Brooklyn, N.Y.; or Ausubel, et al. (1987 and Supplements) Current Protocols in Molecular Biology Wiley / Greene, N.Y.; Innis, et al. (eds.) (1990) PCR Protocols: A Guide to Methods and Applications Academic Press, NY.

[0162] Methods for protein purification include such methods as ammonium sulfate precipitation, column chromatography, electrophoresis, centrifugation, crystallization, and others. See, e.g., Ausubel, et al. (1987 and periodic supplements); Deutscher (1990) “Guide to Protein Purification,”Methods in Enzymology vol. 182, and other volumes in this series; Coligan, et al. (1996 and periodic Supplements) ...

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PUM

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Abstract

Nucleic acids encoding various monocyte cell proteins from a primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.

Description

[0001] This filing is a conversion of, and claims benefit of priority to, provisional U.S. patent applications U.S. Ser. No. 60 / 032,252, filed Dec. 6, 1996; U.S. Ser. No. 60 / 033,181, filed Dec. 16, 1996; and U.S. Ser. No. 60 / 041,279, filed Mar. 21, 1997, each of which is incorporated herein by reference.FIELD OF THE INVENTION [0002] The present invention contemplates compositions related to genes found in monocyte cells, cells which function in the immune system. These genes function in controlling development, differentiation, and / or physiology of the mammalian immune system. In particular, the application provides nucleic acids, proteins, antibodies, and methods of using them. BACKGROUND OF THE INVENTION [0003] The circulating component of the mammalian circulatory system comprises various cell types, including red and white blood cells of the erythroid and myeloid cell lineages. See, e.g., Rapaport (1987) Introduction to Hematology (2d ed.) Lippincott, Philadelphia, Pa.; Jandl (1...

Claims

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Application Information

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IPC IPC(8): C07H21/04C07K14/705C07K16/28C12Q1/68
CPCC07K14/70503C07K16/28C07K2319/00Y10S435/81G01N33/68C07K14/47C07K16/18C12Q1/6876Y10S435/975
Inventor ADEMA, GOSSEMEYAARD, LINDEGORMAN, DANIELMCCLANAHAN, TERRILLZURAWSKI, SANDRAZURAWSKI, GERARDLANIER, LEWISPHILLIPS, JOSEPH
Owner SCHERING CORP