Method for gene identification signature (GIS) analysis

a gene identification and signature technology, applied in the field of gene expression, can solve the problems of prohibitively expensive to tag every transcript in the transcriptome, inability to generate tags to improve specificity, and inability to complete sequencing analysis of all different transcriptomes, etc., to achieve easy recognition, increase the specificity of tags, and enhance sequencing efficiency
US20060084111A1Inactive Publication Date: 2006-04-20AGENCY FOR SCI TECH & RES
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
AGENCY FOR SCI TECH & RES
Publication Date
2006-04-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

An isolated oligonucleotide comprising at least one ditag, wherein the ditag comprises two joined first and second sequence tags, wherein the first tag comprises the 5′-terminus sequence and the second tag comprises the 3′-terminus sequence of a nucleic acid molecule or a fragment thereof. The ditag analysis is useful for gene discovery and genome mapping.
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Description

[0001] This application is a divisional of U.S. Ser. No. 10 / 664,234, filed Sep. 17, 2003.FIELD OF THE INVENTION

[0002] The present invention relates generally to the field of gene and transcript expression and specifically to a method for the serial analysis of a large number of transcripts by identification of a gene signature (GIS) corresponding to defined regions within a transcript. BACKGROUND OF THE INVENTION

[0003] One of the most important goals of the human genome project is to provide complete lists of genes for the genomes of human and model organisms. Complete genome annotation of genes relies on comprehensive transcriptome analysis by experimental and computational approaches. Ab initio predictions of genes must be validated by experimental data. An ideal solution is to clone all full-length transcripts and completely sequence them. This approach has gained recognition recently (Strausberg, R. L., et al., 1999, Science, 286: 455-457) and progress has been made (Jongeneel...

Claims

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