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Method of reducing the risk of retinopathy of prematurity in preterm infants

a technology of prematurity and infants, applied in the field of infant formulas, can solve the problems of not providing the same high level of nutrition, and achieve the effect of promoting retinal health and vision development in infants and reducing the risk or severity of retinopathy

Inactive Publication Date: 2007-07-19
ABBOTT LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent is about a method to reduce the risk and severity of retinopathy of prematurity (ROP) in preterm infants. The method involves measuring the levels of carotenoids in the infants' skin using Raman spectroscopy, and then giving them supplemental carotenoids, specifically lutein, lycopene, beta arotene, and zeaxanthin. The supplemental carotenoids can be added to an infant formula or preterm formula that also contains fat, protein, carbohydrates, vitamins, and minerals. The formula should also contain a specific ratio of lutein to docosahexaenoic acid (DHA) to promote retinal health and vision development in infants. The method is based on the finding that skin carotenoid levels in preterm infants are influenced by the carotenoid levels in human milk, and that supplemental carotenoids can reduce the risk and severity of ROP.

Problems solved by technology

Although many infant formulas provide a quality alternative to human milk, they still do not provide the same high level of nutrition as found in human milk As such, much of the research effort into infant formulas over the past several years has been directed to better understanding the natural constituents of human milk, and then modifying infant formulas accordingly, or at least to the extent possible with currently available technology.

Method used

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  • Method of reducing the risk of retinopathy of prematurity in preterm infants
  • Method of reducing the risk of retinopathy of prematurity in preterm infants
  • Method of reducing the risk of retinopathy of prematurity in preterm infants

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examples

[0076] The following examples represent specific formulas for use in the methods defined herein, each of which is given solely for the purpose of illustration and is not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention. All exemplified amounts are weight percentages based upon the total weight of the composition, unless otherwise specified.

Examples 1.1-1.3

[0077] The following are examples of milk based, ready-to-feed, infant formulas suitable for use in the skin carotenoid methods.

Example 1.1Example 1.2Example 1.3Amount perQuantity perQuantity perIngredient454 kg454 kg454 kgWaterQSQSQSLactose27kg27kg27kgARA-containing oil0.167kg0.167kg0.167kg(40% ARA)DHA-containing oil0.063kg0.095kg0.145kg(40% DHA)Non-fat dry milk11.33kg11.33kg11.33kgHigh oleic safflower oil6.5kg6.5kg6.5kgMono- and di-glycerides0.162kg0.162kg0.162kgSoybean oil5kg5kg5kgWhey protein2.8kg2.8kg2.8kgCalcium ca...

example 5.4

[0112] Skin carotenoid levels are measured in a preterm infant born at 26 weeks gestation, weighing 1.7 kg, age 1 day. Skin carotenoid levels are measured (800 Raman Counts) using non invasive Raman Spectroscopy on the infant's palm. The infant is administered the preterm infant formula of Example 5.2 as a primary form of daily nutrition until discharge. The formula contains lutein, lycopene, beta carotene, and zeaxanthin. Skin carotenoids are measured periodically until discharge to assure adequate carotenoid supplementation as noted by increasing skin carotenoid levels (increased Raman Counts). The infant subsequently experiences minimal or no signs of retinopathy of prematurity.

[0113] The exemplified ready-to-feed formulas (caloric density of 812 kcal / liter) are administered to preterm infants to provide from 7-300 mcg / kg of lutein per day. The administered formula improves eye health as described herein, and are especially useful as applied to preterm infants to reduce the risk...

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Abstract

Disclosed is a method of reducing the risk or severity of retinopathy of prematurity in preterm infants. The method comprises (a) measuring skin carotenoid levels in preterm infants, preferably by Raman Spectroscopy, and then (b) administering supplemental carotenoids to those infants in need thereof, wherein the supplemental carotenoids comprise lutein, lycopene, beta-carotene, and zeaxanthin. The supplemental carotenoids may be provided by an infant formula comprising, on a ready-to-feed basis, from about 100 to about 2000 mcg / liter of total carotenoids, wherein the total carotenoids include at least about 50 mcg / liter of lutein. The formulas may further comprise docosahexaenoic acid.

Description

CROSS-REFERENCE TO RELATED APPLICATION [0001] This application is a continuation-in-part of U.S. Patent Application No. 11 / 584,704, filed Oct. 20, 2006, which makes reference to and claims the benefit of U.S. Provisional Patent Application 60 / 730,283 filed Oct. 26, 2005.TECHNICAL FIELD [0002] The present invention relates to infant formulas and methods for using those formulas to promote retinal health and vision development in infants, including reducing the severity or risk of retinopathy of prematurity. BACKGROUND OF THE INVENTION [0003] Infant formulas are commonly used today to provide supplemental or sole source nutrition early in life. These formulas contain protein, carbohydrate, fat, vitamins, minerals, and other nutrients. They are commercially available as powders, ready-to-feed liquids, and liquid concentrates. [0004] Although many infant formulas provide a quality alternative to human milk, they still do not provide the same high level of nutrition as found in human mil...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K47/00A61K31/12A61K31/015A61B5/00A23L33/00A23L33/15
CPCA23L1/296A23L1/30G01N33/82A23V2002/00A23L1/3006A23L1/305G01N2800/38A23L33/10A23L33/115A23L33/17A23L33/40A61P27/02A23L2/66
Inventor BARRETT-REIS, BRIDGET
Owner ABBOTT LAB INC
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