Method for Transdifferentiating Cells

a technology of transdifferentiating cells and cells, applied in the field of transdifferentiating cells, can solve the problems of difficult control of such cells, inability to control the differentiation direction, and not only the technology requires time and effort to obtain a target cell
US20070298495A1Inactive Publication Date: 2007-12-27KAZUHITO SATOMURA +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
KAZUHITO SATOMURA
Publication Date
2007-12-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

An object of the present invention is to provide a method for transdifferentiating a mature cell without using a DNA methylating agent or a DNA demethylating agent. The present invention provides a method for transdifferentiating a finally differentiated mature cell having a first differentiation phenotype into a finally differentiated mature cell having a second differentiation phenotype that differs from the above first differentiation phenotype by changing culture conditions for the finally differentiated mature cell having the first differentiation phenotype, wherein culture conditions suitable for culturing the finally differentiated mature cell having the above first differentiation phenotype are changed to culture conditions suitable for culturing the finally differentiated mature cell having the above second differentiation phenotype.
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Description

TECHNICAL FIELD

[0001] The present invention relates to a method for transdifferentiating cells. More specifically, the present invention relates to a method for transdifferentiating cells by varying the environment for culturing finally differentiated mature cells. The present invention further relates to differentiated cells that can be obtained by the above method. BACKGROUND ART

[0002] Securing of a source for supplying target cells is essential in any field, based on which regenerative medicine or cellular medicine is realized. Various techniques therefor, such as techniques using stem cells or mature cells, have been developed to date.

[0003] Currently, a merit of pluripotent stem cells represented by embryonic stem cells (ES cells) and mesenchymal stem cells (MSCs) that are mainly used in the field is their pluripotency. At the same time, such cells have many problems, such that control of such cells is difficult because of their pluripotency.

[0004] In the meantime, transdif...

Claims

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