Selective Kinase Inhibitors

a kinase inhibitor and selective technology, applied in the field of selective kinase inhibitors, can solve the problems of difficult design of compounds with acceptable selectivity, inhibiting other members of the family with detrimental long-term consequences, etc., and achieve the effect of suppressing the immune system of a subj
US20080207613A1Inactive Publication Date: 2008-08-28YM BIOSCI AUSTRALIA
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
YM BIOSCI AUSTRALIA
Publication Date
2008-08-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein A represents a variety of six membered nitrogen containing heterocyclic rings, Q is a bond, halogen, C1-4 alkyl, O, S, SO2, CO or CS and X1, X2, X3 and X4 are optionally substituted by 9 specific substituents or one can be nitrogen. Compositions comprising a carrier and at least one compound of formula (I) are also provided. Further provided are methods of treating tyrosine kinase-associated disease states by administering a compound of formula (I) and methods of suppressing the immune system of a subject by administering a compound of formula (I).
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to the field of inhibitors of protein tyrosine kinases in particular the JAK family of protein tyrosine kinases.BACKGROUND OF THE INVENTION

[0002] Protein kinases are a family of enzymes that catalyse the phosphorylation of specific residues in proteins. In general protein kinases fall into several groups; those which preferentially phosphorylate serine and / or threonine residues, those which preferentially phosphorylate tyrosine residues and those which phosphorylate both tyrosine and Ser / Thr residues. Protein kinases are therefore key elements in signal transduction pathways responsible for transducing extracellular signals, including the action of cytokines on their receptors, to the nuclei, triggering various biological events. The many roles of protein kinases in normal cell physiology include cell cycle control and cell growth, differentiation, apoptosis, cell mobility and mitogenesis.

[0003] Protein kinases include, for exa...

Claims

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