Immunogenic Substances Comprising A Polyinosinic Acid-Polycytidilic Acid Based Adjuvant

a polynucleotide complex and immunogenic composition technology, which is applied in the field of immunogenic compositions, can solve the problems of ineffective use of polyinosinic acid-polycytidylic acid (pic), one of the most studied polynucleotide complexes, and inability to provide optimal efficacy/safety profile, and induce unacceptable adverse side effects
US20090175902A1Inactive Publication Date: 2009-07-09YISHENG BIOPHARMA SINGAPORE
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
YISHENG BIOPHARMA SINGAPORE
Publication Date
2009-07-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a polynucleotide adjuvant (PICKCa) composition and methods of use in eliciting an immune response, in particular a mucosal immune response. The polynucleotide adjuvant comprises of a polyriboinosinic-polyribocytidylic acid (PIC), at least one antibiotic and at least one positive ion. The present invention also provides an immunogenic composition comprising the polynucleotide adjuvant composition together with other immunogenic compositions such as an antigen (e.g., as in a vaccine) selected from viral, bacterial, fungal, parasitic and / or cancer antigens. The present invention further contemplates methods of use of such adjuvant compositions, particularly in eliciting an immune response, in particular a mucosal immune response to an antigenic compound.
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Description

FIELD OF INVENTION

[0001] The invention generally relates to immunogenic compositions and methods of their use. More specifically the invention relates to an immunogenic composition comprising a polynucleotide adjuvant in combination with one or more antigenic substances to be used to elicit disease specific immune response in a host.BACKGROUND OF INVENTION

[0002] The immune system may exhibit both specific and nonspecific immunity. Nonspecific immunity encompasses various cells and mechanisms such as phagocytosis (the engulfing of foreign particles or antigens) by macrophages or granulocytes, and natural killer (NK) cell activity, among others. Nonspecific immunity relies on mechanisms less evolutionarily advanced and does not display the acquired nature of specificity and memory, which are exemplary hallmarks of a specific immune response. The key differences between specific and nonspecific immunity are based upon B and T cell specificity. These cells predominantly acquire their resp...

Claims

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