The invention discloses a device and method for detecting the airtightness of a transformer respirator. The device comprises a supporting unit, a measuring unit and a processing unit which are adaptive to a respirator body. The supporting unit comprises a main supporting frame and an auxiliary connecting device. The measuring unit comprises a direct measuring unit and an indirect measuring unit which are distributed on the main supporting frame and the respirator body. The processing unit comprises a receiving unit and a processor and is in wireless connection with the measuring unit. The auxiliary connecting device comprises a measuring connecting frame and a measuring flange plate which are both connected with the respirator body. According to the device, the airtightness detecting fixed value of the respirator is set, under fixed pressure, the parameter information such as the temperature, the humidity, the pressure, the weight and the liquid level of the respirator is measured, airtightness detection is conducted through comparison and judgment, the real breathing normal working state of the respirator can also be simulated, a detection simulation purpose is achieved, and the airtightness detection problem before connecting power equipment is put into operation and in the maintenance process is completely solved.