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System and Method for Estimating Cardiac Pressure Based on Cardiac Electrical Conduction Delays Using an Implantable Medical Device

a technology of electrical conduction delay and cardiac electrical pressure, which is applied in the field of implantable medical devices, can solve the problems of long delay and associated with worsening cardiac status, and achieve the effects of reducing venous return, rapid pacing, and precise calibration

Active Publication Date: 2009-11-19
PACESETTER INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015]In other implementations, both the slope and baseline values are re-calibrated by the implanted device based on newly detected conduction delay values. In still other implementations, to account for the fact that the effective LAP does not reach zero completely during the Valsalva maneuver in some patients (such as heart failure patients with high cardiac filling pressures >20 mmHg and / or with poor cardiac compliance), an additional correction term may be obtained during initial calibration that is used to correct or adjust the re-calibrated values. Preferably, re-calibration is performed while the patient is clinically stable. Moreover, in at least some patients, Valsalva-based re-calibration techniques may not achieve precise calibration due to these factors. Within those patients, other re-calibration techniques are preferably used, which do not necessarily exploit the Valsalva maneuver. In general, any maneuver or condition that significantly affects cardiac pressure within the patient might be exploited for re-calibration purposes. Examples include one or more of: isometric muscle contraction, vasodilatation, vasoconstriction, rapid pacing and performance of the handgrip maneuver. The handgrip maneuver tends to acutely increase LAP. See, e.g., Helfant et al., “Effect of Sustained Isometric Handgrip Exercise on Left Ventricular Performance,” Circulation. 1971;44:982. LAP may be detected estimated using the Swan-Ganz catheter. In some cases, it may be appropriate to employ multiple re-recalibration techniques each yielding new Slope and Baseline values, which are then averaged together to yield the re-calibrated values.

Problems solved by technology

The conduction time delay between the contraction of any two cardiac chambers following either a natural occurring stimulus or an externally administered stimulus is indicative, in at least some patients, of the degree of cardiac failure, such that longer delays may be associated with a worsening cardiac status.

Method used

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  • System and Method for Estimating Cardiac Pressure Based on Cardiac Electrical Conduction Delays Using an Implantable Medical Device

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Embodiment Construction

[0041]The following description includes the best mode presently contemplated for practicing the invention. The description is not to be taken in a limiting sense but is made merely for the purpose of describing the general principles of the invention. The scope of the invention should be ascertained with reference to the issued claims. In the description of the invention that follows, like numerals or reference designators will be used to refer to like parts or elements throughout.

Overview of Implantable Medical System

[0042]FIG. 1 provides a stylized representation of an exemplary implantable pacing medical system 8 capable of detecting electrical conduction delays within the heart of the patient and estimating LAP based on the conduction delays. To this end, implantable system 8 includes a pacer / ICD 10 or other cardiac stimulation device that incorporates internal components (shown individually in FIG. 15, and discussed below) for detecting one or more conduction delays using elec...

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Abstract

Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.

Description

RELATED APPLICATIONS [0001]This application is related to U.S. patent application Ser. No. ______ (Attorney Docket No. A07P3015-US1) of Wenzel et al., entitled, “System and Method for Estimating Cardiac Pressure Based on Cardiac Electrical Conduction Delays Using An Implantable Medical Device,” filed concurrently with this application. This application also claims priority on U.S. Provisional Patent Application No. 60 / 910,060 of Wenzel et al., entitled, “System and Method for Estimating Left Atrial Pressure based on Intra-Cardiac Conduction Time Delays,” filed Apr. 4, 2007, which is fully incorporated by reference herein.FIELD OF THE INVENTION [0002]The invention relates generally to implantable medical devices such as pacemakers and implantable cardioverter defibrillators (ICDs) and in particular to techniques for estimating cardiac pressure (particularly left atrial pressure (LAP)) to detect and evaluate heart failure and related conditions and to automatically adjust pacing param...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N1/36
CPCA61N1/365A61N1/36564A61N1/36578A61N1/3682A61N1/3684A61N1/36842A61N1/36843A61N1/37258A61B5/0215A61B5/02156A61B5/72
Inventor WENZEL, BRIAN JEFFREYGUTFINGER, DAN E.NAWARE, MIHIRMIN, XIAOYISIOU, JEFFERYBJORLING, ANDERSPANESCU, DORIN
Owner PACESETTER INC
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