Manufacturing method of foldable artificial vitreous body and mould thereof

Abstract

The present invention relates to a foldable capsular vitreous body (FCVB), and its mould design, method for manufacturing, product appearance, and drug delivery property and so on. A mould for molding a foldable artificial vitreous body comprises an upper mould (1), a lower mould (2) and a core (3). The core (3) is disposed between the upper mould (1) and the lower mould (2) and is connected with a drainage-tube pin connected with an injection channel (4). Heating holes (6) are disposed in the upper mould (1) and / or the lower mould (2). Material is injected to the mould and is heated to vulcanize to mold vitreous body. The FCVB is adapted to be injected with any harmless medium and can be used as a delivery vehicle inside or around the eye ball. The size or shape of the FCVB can be changed depending on the different implant site.

Description

[0001]This application is a Divisional of application Ser. No. 12 / 841,667, filed Jul. 22, 2010, which is a Continuation of PCT / CN2009 / 000336, filed Mar. 30, 2009, which applications are incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to a foldable capsular vitreous body, and its mould design, method for manufacturing, product appearance, drug delivery property, surgical applications, and so on.BACKGROUND OF THE INVENTION[0003]Currently, national and international studies on substitutes for vitreous body are numerous, mainly including inert gas, silicone oil, heavy silicone oil, perfluorocarbon liquids, and hydrogels composed of high molecular weight hydrophilic polymers being the national or international research focus in the 1990s. However, their therapy results are not satisfying, some of which could result in serious complications, for example, inert gas for instance C3F8 may cause cataract easily and lose the effect of tamponade at abo...

AI Technical Summary

Benefits of technology

The FCVB provides safe, biocompatible, and flexible support to the retina, reducing the risk of retinal detachment, enabling better vision outcomes and minimizing the need for repetitive surgeries by maintaining sustained pressure and facilitating controlled drug delivery.

Problems solved by technology

However, their therapy results are not satisfying, some of which could result in serious complications, for example, inert gas for instance C3F8 may cause cataract easily and lose the effect of tamponade at about two weeks after the surgery such that it could not generate sustained top-pressure on the retina; Perfluorocarbon liquids is toxic to the retina such that it could not settle in the cavity of vitreous body for a long time and could be utilized in surgery only.

Additionally, perfluorocarbon liquids is easy to remain in the eyes and difficult to remove after reaction with water; Present substitutes for silicon oils widely used in clinic could result in glaucoma and cataract and will self-emulsify within a particular time.

Repetitive surgeries not only aggravated the burden of patients but also seriously impaired the vision of the patients; Even though the surgery is successful, the vision of the patients is very poor resulting from that low refractive index of silicon oil could not generate adequate top pressure on the breaks underlying the retina, and that the diopter in eyeball shifted to high hyperopia after filling; Additionally, after surgeries, patients had to lie on stomach for a long time to prevent silicon oil from flowing into the anterior chamber, thus making the patients very agonized.

However, these hydrogels are still at the experimental stage in ophthalmology, and so far no one of these hydrogels is performed in clinic application resulting in lack of observation on the long-term therapeutic effect on the toxicity to the eyes and the price is very high.

The patients could not afford it.

Finding out vitreous substitutes which met physiological needs and are more economical is required, which is one of problems disturbing the doctors for vitreous retinal disorders in the century.

Based on the conditions of modern science and technology, the need to make an artificial vitreous body of which both structure and function are perfect is impractical.

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