Cell collecting device

a cell collection and cell technology, applied in the field of cell collection devices, can solve the problems of difficult recovery and collection of cancer cells from the filter, easy damage of cancer cells, etc., and achieve the effect of easy and efficient collection of target cells

Inactive Publication Date: 2013-10-31
CYTOGEN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]The present cell collecting device is capable of separating target cells from a fluid sample such as blood or physiological fluid and easily and efficiently collecting the target cells. Accordingly, the present cell collecting device is useful in collecting target cells from the human blood for the purpose of analysis, inspection, drug trials and clinical tests.

Problems solved by technology

This poses a problem in that it is quite difficult to recover and collect the cancer cells from the filter.
Another problem lies in that the cancer cells are easily damaged in the process of discharging the cancer cells from the chamber.

Method used

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Experimental program
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Effect test

first embodiment

[0032]The cell collecting device of the first embodiment includes a conduit 10 through which the fluid sample 2 can flow. The conduit 10 includes a passage 12 through which a large amount of fluid sample 2 containing target cells 4 can flow smoothly. The fluid sample 2 is supplied to the upstream end of the conduit 10 by a fluid sample supply means (not shown). Examples of the fluid sample supply means include a syringe, a blood collection tube, a bag, a pack or other containers capable of storing a specified amount of fluid sample and supplying the fluid sample to the upstream end of the conduit 10. The fluid sample supply means may be formed of a syringe pump or a plunger pump for pumping the fluid sample 2. While the passage 12 shown in FIG. 1 has a circular cross section, the present invention is not limited thereto. Alternatively, the passage 12 may be formed into a rectangular cross-sectional shape or other cross-sectional shapes.

[0033]Referring to FIGS. 1 through 6, the cell ...

second embodiment

[0046]Referring to FIGS. 7 through 12, the cell collecting device of the second embodiment includes a first filter 120 installed in the lower portion of the upper passage 114a. The first filter 120 includes a first front surface 122, a first rear surface 124, a plurality of first pores 126 and four locating grooves 138. The first pores 126 are formed to have a cross-sectional area large enough to allow the target cells 4 to pass through the first pores 126. Each of the first pores 126 includes corner portions 128 formed into a round shape. Each of the first pores 126 has a substantially rectangular shape and includes a pair of first transverse sides 130 extending parallel to each other and a pair of first longitudinal sides 132 extending parallel to each other. The length L5 of the first transverse sides 130 is equal to the length L6 of the first longitudinal sides 132. The first filter 120 includes a plurality of first transverse strips 134 and a plurality of first longitudinal str...

third embodiment

[0056]In the cell collecting device of the third embodiment, if the male thread portion 214b is completely tightened to the female thread portion 216b, the second front surface 242 of the second filter 240 comes into contact with the first rear surface 224 of the first filter 220. If the fluid sample 2 is supplied to the upstream end of the upper conduit part 214, the target cells 4 contained in the fluid sample 2 flowing along the passage 212 are obstructed by the first transverse strips 234, the first longitudinal strips 236, the second transverse strips 254 and the second longitudinal strips 256 and cannot pass through the split holes 226a, 226b, 226c and 226d. Non-target cells are moved through the split holes 226a, 226b, 226c and 226d and are then discharged out of the conduit 210.

[0057]Referring to FIGS. 16 and 17, if the flow sample 2 is completely discharged, the male thread portion 214b and the female thread portion 216b are loosened by rotating one of the upper conduit par...

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Abstract

A cell collecting device is configured to collect target cells from a fluid sample such as blood or physiological fluid. The cell collecting device includes a first filter having a plurality of first pores formed into a size that enables target cells contained in a fluid sample to pass through the first pores, and a second filter having a plurality of second pores formed into a size that enables the target cells contained to pass through the second pores. The second filter is arranged below the first filter in such a position as to filter the target cells.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a cell collecting device and, more particularly, to a cell collecting device capable of filtering and collecting target cells from a fluid sample such as blood or physiological fluid.BACKGROUND OF THE INVENTION[0002]In recent years, regulations are increasingly strengthened on a biological test and a clinical test conducted for the sake of treatment of human diseases. As an alternative for the biological test and the clinical test, research and development have been extensively made on the collection of live cells from the human blood. The collection of cells is conducted by different kinds of cell collecting devices such as a micro-fluidic device, a CTC (Circulating Tumor Cell) chip, a filter, and so forth.[0003]As one example of the cell collecting device, U.S. Patent Publication No. 2007 / 0025883A1 discloses a parylene membrane filter for filtering cells from fluid. The membrane filter is installed within a chamber and i...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N1/34
CPCG01N1/34C12M47/04C12M47/02B01L3/50255G01N1/4077G01N2001/4088
Inventor JEON, BYUNG HEELEE, JONG KIL
Owner CYTOGEN CO LTD
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