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Wound debridement compositions containing seaprose and methods of wound treatment using same

a technology of enzymatic debridement composition and composition, which is applied in the direction of drug composition, oil/fat/waxes non-active ingredients, peptide/protein ingredients, etc., can solve the problems of wounds being present on the skin of people, epidermal and/or dermal layer of the skin being damaged, and affecting the healing effect of wounds, etc., to achieve the effect of enhancing the enzymatic debridement activity

Inactive Publication Date: 2014-06-05
SMITH & NEPHEW ORTHOPAEDICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent is about a new type of composition and method that can help clean and remove dead skin cells. The new feature is that this composition works better at breaking down the proteins that make up the dead skin cells. This patent also describes how to use this new composition to improve skin health and reduce the appearance of wrinkles.

Problems solved by technology

The wound can be present on a person's skin (e.g., the epidermal and / or dermal layer of the skin can be damaged).
Again, the wound can be present on a person's skin (e.g., the epidermal and / or dermal layer of the skin can be damaged).
The wound can be present on a person's skin (e.g., the epidermal and / or dermal layer of the skin can be damaged).

Method used

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  • Wound debridement compositions containing seaprose and methods of wound treatment using same
  • Wound debridement compositions containing seaprose and methods of wound treatment using same

Examples

Experimental program
Comparison scheme
Effect test

example 1

Exemplary Formulations

[0050]The following Tables provide non-limiting examples of formulations containing Seaprose of the present invention:

TABLE 1Gel*Ingredient% Concentration (by weight)SEAPROSE S1.0Tris Buffer Solution 10 mM (pH 7.5)96.4Hydroxyethylcellulose (HEC)2.6TOTAL100*Process: A gel was made with the HEC and Tris buffer. SEAPROSE S was admixed with the HEC gel. The viscosity of the gel gradually reduced over time possibly due to the amylase present in the Seaprose material degrading the HEC.

TABLE 2Gel*Ingredient% Concentration (by weight)SEAPROSE S1.0CURASOL ® Gel Wound Dressing99.0TOTAL100*Process: SEAPROSE S was admixed with the CURASOL Gel Wound Dressing to form a clear gel. The viscosity was maintained over time.

TABLE 3Cream*Ingredient% Concentration (by weight)SEAPROSE S0.5Tris Buffer Solution 10 mM (pH 7.5)71.52Glycerin7.0Methylparaben0.2Propylparaben0.08Emulsifying Wax15.2Isopropyl Palmiitate NF5.5TOTAL100*Process: Methylparaben, propylparaben and glycerin were diss...

example 2

In Vitro Digestion of Pig Burn Eschar

[0051]The gel formula in Table 1 (1% Seaprose Gel) and each of the following two gel formulas (1% Thermolysin Gel and 10% Bromelain Gel) were used in an in-vitro study to compare the degradation of pig eschar by each gel formula.

TABLE 51% Thermolysin GelIngredient% Concentration (by weight)Thermolysin (Sigma-Aldrich)1.0Tris Buffer Solution 10 mM (pH 7.5)95.1Hydroxyethylcellulose (HEC)2.9Sodium Chloride0.9Calcium Chloride0.1TOTAL100

TABLE 610% Bromelain GelIngredient% Concentration (by weight)Bromelain (Spectrum)10.0Water84.6Carbomer 980K1.9Disodium Phosphate2.64-Chloro-3-Methylphenol0.1Sodium Hydroxide0.8TOTAL100

[0052]The study was conducted in-vitro using eschar materials obtained from pig burn wounds. The eschar materials were dried completely. The dry weight was used as baseline. Samples of the dried eschar weighing 40-60 mg were moisturized with 50 μl of Tris buffered saline. The moisturized eschar samples were immersed in 3 g of each of the t...

example 3

In Vivo Debridement of Pig Burn

[0054]In this in vivo pig study, eschars were formed on the backs of pigs by introducing burn wounds using heated brass rods and allowing the formation of dry eschars over several days. There was a visual effect of Seaprose (SAP) on many wounds in comparison to control after one day of treatment (FIG. 2). Overall, SAP exhibited more rapid complete debridement of the eschars when compared against a control (non-adherent pre-moistened wound dressing with saline) (FIG. 3).

[0055]The particulars of this in vivo study are as follows. Pigs were anesthetized, the torso shaved with clippers and a razor, and washed with vedadine. Then an isopropyl rinse was performed to sterilize the surgical field. Twenty 2-cm wounds were created on the dorsum of each pig. The wounds were created using solid brass rods, heated to 100° C. in sand baths, held on the skin for 45 seconds. The wounds were left to dry for five days, giving the eschars time to form, with protective fo...

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Abstract

Wound debridement compositions containing the proteolytic enzyme Seaprose and use of such compositions in wound treatment for the enzymatic debridement of wounds.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application No. 61 / 485,503, filed May 12, 2011. The contents of the referenced application are incorporated into the present application by reference.BACKGROUND OF THE INVENTION[0002]A. Field of the Invention[0003]The present invention generally relates to methods and compositions useful for the debridement and treatment of wounds. More specifically, the present invention is related to enzymatic wound debridement compositions comprising Seaprose and methods of wound treatment using same.[0004]B. Background of the Invention[0005]The healing of wounds is a complex process which is often further complicated by the presence of nonviable necrotic tissue in the wound area. The presence of eschar and other necrotic tissue in a wound can impede the healing process causing the wound to become a slow-healing or “chronic” wound. Wounds such as diabetic foot ulcers, venous leg ulcers, arterial l...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/48
CPCA61K38/482A61K9/0014A61K9/06C12Y304/21063A61P17/02A61P43/00A61K9/0019A61K47/06A61K47/10A61K47/38A61K47/44
Inventor SHI, LEIJOVANOVIC, ALEKSACARSON, DENNIS
Owner SMITH & NEPHEW ORTHOPAEDICS
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