Meniscus for joint reconstruction

a meniscus and joint technology, applied in the field of meniscus for joint reconstruction, can solve the problems of affecting the function of hand muscles,

Inactive Publication Date: 2016-05-19
CEDARS SINAI MEDICAL CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]Various embodiments of the present invention provide a kit for treating a subject. In various embodiments, the kit may comprise or may consist essentially of or may consist of: comprising: an implant as disclosed herein; and instructions for using the implant to treat the subject. In various embodiments, the kit further comprises one or more securements for securing the implant into the subject's joint. In accordance with the present invention, the securement can be a suture, anchor, suture anchor, fibrin glue, screw, bolt, nail, pin, staple, fastener, ligament, or adhesive, or a combination thereof.
[0011]Various implants, methods and kits of the present invention find utility in the treatment of various medical conditions of joints, for example, small joints like finger and hand joints, medium joints like wrist joints, and large joints like shoulder joints.

Problems solved by technology

The most common cause of disability among US adults is damaged or arthritic small joints in the hand.
Patients feel severe pain and have limited hand function.
However, synthetic joint implants are subject to infection, and may loosen or break over time, leaving patients with lasting pain or in need of follow-up surgeries.

Method used

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  • Meniscus for joint reconstruction
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Examples

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example 1

A Novel Use of Meniscus for Small Joint Reconstruction of the Hand

[0096]Small joint arthroplasty of the hand has mixed outcomes and no ideal implant has been developed. Various materials have been used in the past with mixed results. One of the classic reconstruction modalities is the silicone implant however one of the major drawbacks is that up to 40% of implants will break over long term follow up. Pyrolytic carbon is another synthetic substance which has been used with continued mixed results. This invention provides a novel approach for small joint reconstruction: using cadaveric meniscus for joint reconstruction. Meniscus is advantageous as it is amenable to a synovial environment, can be revascularized, has a low metabolic demand, and is malleable.

[0097]The inventor reconstructed three metacarpophalangeal (MCP) and one proximal interphalangeal joint (PIP) in four patients using cadaveric meniscus. Patient demographic, pre- and post-operative pain and range of motion data was ...

example 2

Wrist Salvage of the Radiocarpal Joint Using Cadaver Meniscus

[0102]In the setting of wrist salvage, proximal row carpectomy (PRC) and scaphoidectomy with four-corner fusion (4CF) are effective motion-preserving and pain-relieving therapies. Effective treatment necessitates that the capitolunate joint remains free of osteochondral defects to achieve pain-free motion and healing. In patients with severe arthritis in the capitolunate joint, we propose a novel adjunct for PRC wrist joint salvage using cadaveric meniscus for joint resurfacing. It is an off-the-shelf alternative that is not only malleable but also addresses focal osteochondral effects and restores intra-articular contact stress distributions toward normal levels.

[0103]The inventors reconstructed three radiocapitate joints with osteochondral defects using cadaveric meniscus to facilitate PRC of the wrist and preserve pain-free motion. Patient demographic, pre and post-operative pain and range of motion data was examined as...

example 3

Tissue Engineering Using Cadaveric Meniscus for Arthroplasty of the Hand: Long Term Outcomes

[0106]The use of small joint arthroplasty implants has been tinctured with mixed short and long term outcomes over the past 50 years. There have been several synthetic, non-biological materials developed to help recreate joint function. One classic reconstruction method utilizes silicone implants which initially provide excellent mechanical properties, however over the long term, up to 40% of these breaks or loses function. The ideal reconstruction would provide the biomechanical properties of the joint, but would also be biointegrated or at least biologically inert. One reconstructive approach involves the use of naturally derived human meniscus. As a biomaterial, meniscus is amenable to a synovial environment, it can be revascularized and biointegrated, it has a relatively low metabolic demand, and it is incredibly malleable. Described herein, cadaveric meniscuses are used for small joint r...

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Abstract

The invention provides treatment methods of using meniscus to repair injured and/or arthritic joints, for example, small hand joints including but not limited to radiocarpal, metacarpophalangeal, and interphalangeal joints. The invention also provides various implants made of meniscus for injured and/or arthritic joints.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application includes a claim of priority under 35 U.S.C. §119(e) to U.S. provisional patent application No. 62 / 082,033, filed on Nov. 19, 2014, the contents of which are herein incorporated by reference in its entirety as though fully set forth.FIELD OF THE INVENTION[0002]The invention relates to methods and implants for reconstructing joints.BACKGROUND[0003]All publications cited herein are incorporated by reference in their entirety to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. The following description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.[0004]The most common cause of disability among...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F2/30
CPCA61F2/30756A61F2002/30764A61F2002/30757
Inventor KULBER, DAVID A.
Owner CEDARS SINAI MEDICAL CENT
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