Methods, computer-accessible medium and systems to model disease progression using biomedical data from multiple patients

Abstract

An exemplary embodiment of system, method and computer-accessible medium can be provided to reconstruct models based on the probabilistic notion of causation, which can differ fundamentally from that can be based on correlation. A general reconstruction setting can be complicated by the presence of noise in the data, owing to the intrinsic variability of biological processes as well as experimental or measurement errors. To gain immunity to noise in the reconstruction performance, it is possible to use a shrinkage estimator. On synthetic data, the exemplary procedure can outperform currently known procedures and, for some real cancer datasets, there are biologically significant differences revealed by the exemplary reconstructed progressions. The exemplary system, method and computer accessible medium can be efficient even with a relatively low number of samples and its performance quickly converges to its asymptote as the number of samples increases.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application relates to and claims priority from U.S. Patent Application No. 61 / 896,566, filed on Oct. 28, 2013, U.S. Patent Application No. 62 / 038,697, filed on Aug. 18, 2014, and U.S. Patent Application No. 62 / 040,802, filed on Aug. 22, 2014, the entire disclosures of which are incorporated herein by reference.FIELD OF THE DISCLOSURE[0002]The present disclosure relates generally to cancer progression models, and more specifically, to exemplary embodiments of an exemplary system, method and computer-accessible medium for a determination of cancer progression models, which can include noise and / or biological noise and / or can use biological data from multiple patients.BACKGROUND INFORMATION[0003]Cancer is a disease of evolution. Its initiation and progression can be caused by dynamic somatic alterations to the genome manifested as point mutations, structural alterations of the genome, DNA methylation and histone medication changes. (Se...

AI Technical Summary

Benefits of technology

[0008]In some exemplary embodiments of the present disclosure, the biomedical data can include genomics, transcriptomics, epigeneomics or imaging data and / or can include information pertaining to a normal cell(s), a tumor cell(s), cell-free circulating DNA or a circulating tumor cell(s). The states of the disease can be determined by genomics, transcriptomics or epigeneomics mutational profiles, and / or by a causality relationship whose strength is estimated by probability-raising by an unbiased estimator(s). The unbiased estimator can include a shrinkage estimator(s), which can be a measure of causation among any pair of events atomic events.

Problems solved by technology

Different progression sequences can be used, although some can be more common than others, and not every order can be viable.

However, unfortunately, the causal and temporal relations among the genetic events driving cancer progression remain largely elusive.

Extracting this dynamic information from the available static, or cross-sectional data can be a challenge, and the combination of mathematical, statistical and computational techniques can be needed to decipher the complex dynamics.

The results of the research addressing these issues will have important repercussions for disease diagnosis and prognosis, and therapy.

However, in these cases, other constraints on the joint occurrence of events can be imposed.

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