Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof

Inactive Publication Date: 2017-01-26
BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0024]The invention also provides methods for the treatment or prevention of parasitic infections and infestations in animals, comprising administering an effective amount of extended release injectable formulations comprising an antiparasitic effective amount of at least one isoxazoline compound together with a pharmaceutically acceptable polymer and a solvent. Surprisingly, it has been found that the i

Problems solved by technology

Likewise, for the purposes of this application, liquid polyethylene glycols (PEGs) that are not co-polymerized with other pharma

Method used

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  • Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
  • Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
  • Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof

Examples

Experimental program
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Example

Formulation Examples

[0854]The following extended release injectable formulations were prepared by mixing the following ingredients. Unless indicated otherwise, the concentrations of each component is percent (%) weight per weight (w / w) and MW refers to weight average molecular weight.

Example

Example 1

[0855]

Compound of formula (IIc)  26%Medium molecular weight (MMW) PLGA (50:50)   1%Propylene carbonate50.9%Triacetin22.2%BHT0.02%.

Example

Example 2

[0856]

Compound of formula (IIc)  26% Low molecular weight (LMW) PLGA (50:50)   5%Propylene carbonate 48.0% Triacetin 21.0% BHT 0.02%.

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Abstract

This invention relates to extended release injectable formulations for combating parasites in animals, comprising at least one isoxazoline active agent, a pharmaceutically acceptable polymer, and a solvent. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the extended release injectable formulations of the invention to the animal in need thereof.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application No. 62 / 144,871 filed on Apr. 8, 2015, which is herein incorporated by reference.FIELD OF THE INVENTION[0002]The present invention provides extended release injectable formulations comprising at least one isoxazoline active agent, a pharmaceutically acceptable polymer and a solvent; the use of these formulations against parasites (including ectoparasites (e.g., fleas or ticks) and / or endoparasites), and methods for preventing or treating parasitic infections and infestations in animals.BACKGROUND OF THE INVENTION[0003]Animals such as mammals and birds are often susceptible to parasite infestations / infections. These parasites may be ectoparasites, such as fleas, ticks and parasitic flies, and endoparasites such as nematodes and other worms. Domesticated animals, such as cats and dogs, are often infested with one or more of the following ectoparasites:[0004]fleas (e.g. Cteno...

Claims

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Application Information

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IPC IPC(8): A61K31/42A61K9/00
CPCA61K9/0019A61K31/42A61K9/00A61K31/422A61K47/10A61K47/22A61K2300/00A61P33/00A61P33/14A61K47/30
Inventor CADY, SUSAN MANCINICHEIFETZ, PETERGALESKA, IZABELADE FALLOIS, LOIC LE HIR
Owner BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC
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