Multilayer Compositions, Coated Devices And Use Thereof

a technology of coating device and composition, applied in the direction of viruses/bacteriophages, antibody medical ingredients, dna/rna vaccination, etc., can solve problems such as conversion and instability, and achieve the effects of reducing the risk of developing pathology, and reducing the severity

Inactive Publication Date: 2017-09-14
MASSACHUSETTS INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0025]“Treating”: As used herein, the term refers to any method used to partially or completely alleviate, ameliorate, relieve, inhibit, prevent, delay onset of, reduce severity of and/or reduce incidence of one or more symptoms or features of a particular d

Problems solved by technology

In some embodiments, a release layer is or comprises a polymer, which is stable during deposition/assembly onto a subs

Method used

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  • Multilayer Compositions, Coated Devices And Use Thereof
  • Multilayer Compositions, Coated Devices And Use Thereof
  • Multilayer Compositions, Coated Devices And Use Thereof

Examples

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example 1

[0111]In this Example, rapid hypodermic-needle-free DNA delivery was demonstrated, using microneedle patches that implant multi-layer polymer films into the epidermis following a brief application to skin. Biodegradable multi-layer films carrying DNA, a polymeric transfection agent, and adjuvant molecules implanted in murine skin both efficiently transfected cells in the local tissue and elicited immune responses comparable to in vivo electroporation of plasmid DNA (pDNA), one of the most promising current technologies for DNA vaccine delivery.

[0112]To substantially enhance DNA vaccine delivery, an approach was designed to simultaneously (i) improve targeting of DNA to tissues rich in immune response-governing dendritic cells, (ii) promote sustained transfection without toxicity, (iii) and provide supporting inflammatory cues to enhance the induction of a potent immune response. To this end, a strategy was developed using microneedles to rapidly and painlessly implant biodegradable ...

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Abstract

The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a structure, comprising a substrate and a multilayer film on the substrate, wherein the multilayer film comprises a release layer and one or more layer-by-layer films. In some embodiments, a structure comprising a microneedle substrate and a multilayer film coated on at least portion of the microneedle substrate, wherein the multilayer film comprises an agent for delivery.

Description

RELATED APPLICATION(S)[0001]This application is a continuation of U.S. application Ser. No. 14 / 435,057, filed Apr. 10, 2015, which is the U.S. National Stage of International Application No. PCT / US2013 / 064530, filed on Oct. 11, 2013, published in English, which claims the benefit of U.S. Provisional Application No. 61 / 713,457, filed on Oct. 12, 2012. The entire teachings of the above applications are incorporated herein by reference.BACKGROUND OF THE INVENTION[0002]Layer-by-Layer (LBL) assembly of multilayer film coatings is driven by the alternating deposition of materials (e.g., polymers with complementary electrostatic functionalities). The LBL assembly process produces nanometer to micron scale thin film coatings. A major benefit of LBL assembly is the potential to achieve controlled and sequential delivery of agents by tuning the deposition of these agents at specific layers within the film.[0003]There is a particular interest in achieving delivery of vaccines and / or therapeuti...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K9/00
CPCA61K9/7007A61K9/0021C12N2740/16234A61K2039/55511A61K2039/53A61K9/5084C12N7/00B05D1/36A61K47/34A61K47/32A61K39/21C12N15/89
Inventor DEMUTH, PETER C.MIN, YOUNJINIRVINE, DARRELLHAMMOND, PAULA T.
Owner MASSACHUSETTS INST OF TECH
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