Applications for estradiol in preparing Anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma products

a technology of ovarian cancer and estradiol, applied in the field of biochemistry, can solve the problems of not being effective, not well understood, and new medications are expensive, and achieve the effect of inhibiting the proliferation

Inactive Publication Date: 2018-07-05
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the bottlenecks of large investments required in the development of new medications and the long-time periods cannot be overcome, as well as the great individual variation in tumor genetics, many traditional anti-cancer medications are not very effective, new medications are expensive, and side effects are not well understood.

Method used

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  • Applications for estradiol in preparing Anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma products
  • Applications for estradiol in preparing Anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma products
  • Applications for estradiol in preparing Anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029]Unless otherwise specified, the experimental methods employed in the following examples are standard methods.

[0030]Materials, reagents, etc. used in the following examples are all commercially available unless otherwise specified, and the experimental methods employed in the following examples are standard methods.

[0031]The analyte drug in the following examples is estradiol, and its chemical composition is:

[0032]It is a drug bank product with a catalog number of DB00783.

[0033]In the examples below, the product sources for the NCI-H82 small-cell lung cancer cells, the SKOV-3 ovarian cancer cells, the SNU-475 and NCI-H810 human hepatoma cells, and the U2OS osteosarcoma cells are as follows:

NCI-H810ATCCCRL-5816NCI-H82ATCCHTB-175SKOV-3ATCCHTB-77SNU-475ATCCCRL-2236U2OSECACC92022711

[0034]The primary instruments and materials in the examples below are:

[0035]DMSO (from Sigma, Cat. No. D4540)

[0036]96-well clear bottom cell culture plates (from Corning, Cat. No. 3610)

[0037]CellTiter Gl...

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Abstract

This invention discloses uses for estradiol in preparing anti-small cell lung cancer and / or ovarian cancer and / or osteosarcoma products. This invention provides uses for estradiol in preparing anti-small cell lung cancer and / or ovarian cancer and / or osteosarcoma products. From carrying out cancer drug repositioning for the FDA- and CFDA-approved drug estradiol, experiments for this invention show, based on screening of non-anti-cancer drugs for various cancer cell lines (tissue types) and mutation sites, that estradiol has a new use as an anti-small cell lung cancer and / or ovarian cancer and / or osteosarcoma medication, thus achieving a new purpose for an old drug.

Description

TECHNICAL FIELD[0001]The present invention relates to the technical field of biology, and it particularly relates to the application of estradiol in the preparation of anti-small cell lung cancer and / or ovarian cancer and / or osteosarcoma products.BACKGROUND[0002]Cancer is the most common as well as the most serious disease that threatens human health, and developing effective anti-cancer medications is critical to extending patients' lives. Along with the rapid development of cancer genomics and molecular pharmacology in recent years, the development of new anti-cancer medications has had relatively good outcomes. However, since the bottlenecks of large investments required in the development of new medications and the long-time periods cannot be overcome, as well as the great individual variation in tumor genetics, many traditional anti-cancer medications are not very effective, new medications are expensive, and side effects are not well understood.[0003]In a paper published by th...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/565A61P35/00
CPCA61K31/565A61P35/00
Inventor SHI, YONGYONGSONG, ZHIJIAN
Owner SHANGHAI JIAO TONG UNIV
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