Polypeptide derivatives from grass carp interferon and application thereof

a technology of interferon and polypeptide, which is applied in the field of biotechnology, can solve the problems of creating a huge threat to human health and the development of aquaculture, and achieve the effects of reducing the toxicity of peptides, and reducing the risk of infection
US20190359673A1Active Publication Date: 2019-11-28HUAZHONG AGRI UNIV
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
HUAZHONG AGRI UNIV
Publication Date
2019-11-28

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Abstract

Derivative polypeptide derived from a grass carp interferon and an application of the derivative polypeptide. An amino acid sequence of the derivative polypeptide is as shown in SEQ ID NO:1; the interferon-derived polypeptide has a high-efficiency antibacterial effect and can take effect against drug-resistant Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus agalactiae, Vibrio fluvialis or Aeromonas hydrophila. The interferon-derived polypeptide is less toxic to eukaryotes and can effectively reduce the mortality of mice in a mouse disease model caused by pathological bacteria. The interferon-derived polypeptide which is small in molecular weight is easily synthesized and has a good application value.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] The subject application claims priority on Chinese application no. CN 201810503117.X filed on May 23, 2018. The contents and subject matters of the Chinese priority application is incorporated herein by reference.REFERENCE TO SEQUENCE LISTING

[0002] The official copy of the Sequence Listing is submitted concurrently with the specification as an ASCII formatted text file via EFS-Web, with a file name of “SequenceListing8006wh_ST25.txt”, a creation date of May 22, 2019, and a size of 595 bytes. The Sequence Listing filed via EFS-Web is part of the specification and is incorporated in its entirety by reference herein.BACKGROUND OF THE INVENTIONTechnical Field

[0003] The present invention belongs to the field of biotechnology, and particularly relates to a derivative polypeptide derived from a grass carp interferon and an application thereof.Description of Related Art

[0004] Traditional antibiotics have made certain achievements in the treatment of...

Claims

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