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Toxoplasma gondii vaccines and their use
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a technology of toxoplasma gondii and vaccines, which is applied in the field of intracellular parasites, can solve the problems of toxic or hypersensitivity, inability to eliminate latent parasites, and cyst forms that cannot be eliminated
Inactive Publication Date: 2020-09-17
EMERGENT TRAVEL HEALTH INC +1
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Benefits of technology
The chimeric polypeptide and adjuvant combination induces significant CD8+ T cell responses, reduces parasite burden, and provides protective immunity against Toxoplasma gondii infection in HLA-A*1101 transgenic mice.
Problems solved by technology
Although antiparasitic medicines such as sulfadiazine and pyrimethamine are effective against tachyzoites, they are associated with toxicity or hypersensitivity and do not eliminate the latent, cyst form of the parasite.
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[0186]“Tox-A11” is another example of a SAPN. Tox-all follows the same principle as the A11 SAPN (SEQ ID NO:27) but it has multiple components to stimulate diverse HLA haplotype CD8 T cells, CD4Tcells, B cells to make antibody, and contains the TLR5 ligand flagellin. These are included to stimulate multiple arms of the immune response. This is called “Tox-A11” to reflect all the components. The sequence of Tox-A11 is:
(SEQ ID NO: 28)(MGDDHHHHHHHHHH)WFMGVLVNSLQDITMGSLFFVQDFMIVSISLVQDGLAAAVVAVQDLPQFATAATRDSPASGRYIQQMLDQRCQEIAAELCQSGLRKMCVPSSRIVARNAVGITHQNTLQWRCFDTASLLESNQENNGVNCVDDCGHTIPCPGGVHRQNSNHATRHEILSKLVEEGVQRFCSPYQASANKYCNDKFPGTIARRSKGFGNNVEVAWRCYEKASLLYSVYAECASNCGTTWYCPGGRRGTSTELDKRHYTEEEGIRQAIGSVDSPCSEVEVCLPKDENPPLCLDESGQISRGSWEEWNARWDEWENDWNDWREDWQAWRDDWARWRATWMGGRLLSRLERLERRNEELRRLLQLIRHENRMVLQFVRALSMQNAELERRLEELARGMAQVINTNSLSLLTQNNLNRSQSALGTAIERLSSGLRINSARDDAAGQAIANRFTANIRGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVRVLAQDNTLTIQVGANDGETIDIDLRQ...
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Abstract
Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.
Description
CROSS REFERENCE[0001]This application claims priority to U.S. Provisional Patent Application Ser. No. 62 / 324,225 filed Apr. 18, 2016, incorporated by reference herein in its entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH[0002]This invention was made with U.S. government support under grant numbers DMID-NIAID U01 AI77887, RO1 27530, and U19 A1110819, all awarded by The National Institutes of Health. The U.S. Government has certain rights in the invention.BACKGROUND[0003]Toxoplasma gondii is an intracellular parasite that can cause severe ocular and neurological diseases in fetuses, newborn infants, and immunocompromised individuals (1). The acute infection is characterized by proliferation of tachyzoites, which replicate rapidly within host cells and lyse their host cells within 24-48 hours to release large numbers of progeny. In response to immune pressure, the parasite differentiates into a slow-growing form called bradyzoites, which resides within intracellular cysts. F...
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Patent Type & Authority Applications(United States)
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