Azabicyclooctane derivatives useful in the treatment of cardiac arrhythmias

a technology of azabicyclooctane and derivatives, which is applied in the direction of biocide, drug composition, cardiovascular disorder, etc., can solve problems such as (turning points
US6559162B2Inactive Publication Date: 2003-05-06ASTRAZENECA AB
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
ASTRAZENECA AB
Publication Date
2003-05-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

Compounds of formula I,wherein R1, R2, R3 and Ra Rh are as defined in the specification. The compounds are useful in the prophylaxis and in the treatment of arrhythmias, in particular a trial and ventricular arrhythmias.
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Description

This application is a 371 of PCT / SE00 / 02064 filed Dec. 19, 2000, now WO 01 / 47893 Jul. 5, 2000.This invention relates to novel pharmaceutically useful compounds, in particular compounds which are useful in the treatment of cardiac arrhythmias.BACKGROUND AND PRIOR ARTCardiac arrhythmias may be defined as abnormalities in the rate, regularity, or site of origin of the cardiac impulse or as disturbances in conduction which causes an abnormal sequence of activation. Arrhythmias may be classified clinically by means of the presumed site of origin (i.e. as supraventricular, including atrial and atrioventricular, arrhythmias and ventricular arrhythmias) and / or by means of rate (i.e. bradyarrhythmias (slow) and tachyarrhythmias (fast)).In the treatment of cardiac arrhythmias, the negative outcome in clinical trials (see, for example, the outcome of the Cardiac Arrhythmia Suppression Trial (CAST) reported in New England Journal of Medicine, 321, 406 (1989)) with "traditional" antiarrhythmic d...

Claims

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