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Injectable microspheres for tissue construction,Injectable microspheres for tissue construction,Smart bio-nanoparticle elements,ACE-2 inhibiting compounds and methods of use thereof,Amidino derivatives and their use as thrombin inhibitors

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Injectable microspheres for tissue construction

InactiveUS20030211083A1Used accurately and convenientlyMore efficaciousBiocidePowder deliveryMicrosphereMedicine

The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue construction and generation. The invention also relates to methods of tissue construction and generation, for the treatment of various tissue damage and defects, using the injectable compositions.

Owner:BIOSPHERE MEDICAL INC

Injectable microspheres for tissue construction

InactiveUS7338657B2Used accurately and convenientlyMore efficaciousPowder deliveryBiocideMedicineMicrosphere

Owner:BIOSPHERE MEDICAL INC

Smart bio-nanoparticle elements

ActiveUS7393924B2Inhibition of charge transferReduce restrictionsUltrasonic/sonic/infrasonic diagnosticsMaterial nanotechnologyProtein moleculesNanoparticle

The invention in suitable embodiments is directed to isolated bio-nanoparticle elements and isolated bio-nanoparticle platforms employing such isolated bio-nanoparticle elements. In one aspect, the isolated bio-nanoparticle elements are formed with purified Clathrin and or with purified coatomer I / II self-assembling protein molecules.

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Owner:METAQOR

ACE-2 inhibiting compounds and methods of use thereof

InactiveUS6632830B1Inhibit functioningReduce riskOrganic active ingredientsBiocideBlood pressureKidney disorder

ACE-2 inhibiting compounds are disclosed. These compounds include compounds of formula (IV):wherein the variables are as described in the specification. Pharmaceutical compositions containing the compounds are also discussed. The pharmaceutical compositions may contain an effective amount of a compound of the invention to treat ACE-2 associated disorders such as a blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder.< / PTEXT>

ACE-2 inhibiting compounds and methods of use thereof

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Owner:MILLENNIUM PHARMA INC

Amidino derivatives and their use as thrombin inhibitors

InactiveUS6221898B1More efficaciousToxic reductionBiocidePeptide/protein ingredientsAmidino derivativeThrombin activity

There is provided compounds of formula I,wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Amidino derivatives and their use as thrombin inhibitors

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Owner:ASTRAZENECA AB

Treatment regimen for administration of phenylacetylglutamine, phenylacetylisoglutamine, and/or phenylacetate

InactiveUS6943192B2High plasma concentrationFull penetrationBiocidePeptide/protein ingredientsDiseasePhenylacetylglutamine

Herein is disclosed a method of treating neoplastic disease, including cancer, comprising administering a pharmaceutical composition, the pharmaceutical composition comprising a highly concentrated aqueous solution of phenylacetylglutamine and phenylacetylisoglutamine in a 4:1 ratio, at an infusion rate of from 100 mL / hr to 400 mL / hr. In a further embodiment, herein is also disclosed a method of treating neoplastic disease, including cancer, comprising administering a pharmaceutical composition, the pharmaceutical composition comprising a highly concentrated aqueous solution of phenylacetate and (phenylacetylglutamine or phenylacetylisoglutamine) in a 4:1 ratio, at an infusion rate of from 100 mL / hr to 400 mL / hr. Herein are also disclosed the pharmaceutical compositions used in the above methods.

Treatment regimen for administration of phenylacetylglutamine, phenylacetylisoglutamine, and/or phenylacetate

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Owner:BURZYNSKI STANISLAW R

Amidino derivatives and their use as thrombin inhibitors

InactiveUS6265397B1More efficaciousToxic reductionBiocideOrganic chemistryThrombusAmidino derivative

There is provided compounds of formula I,wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

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Owner:ASTRAZENECA AB

Amino acid derivatives and their use as thrombin inhibitors

InactiveUS6255301B1More efficaciousToxic reductionSilicon organic compoundsBiocideAnticoagulantThrombin activity

There is provided compounds of formula I,wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required as in thrombosis or as anticoagulants.

Amino acid derivatives and their use as thrombin inhibitors

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Owner:ASTRAZENECA AB

Positive modulators of nicotinic acetylcholine receptors

InactiveUS20070179172A1More efficaciousLonger actingBiocideNervous disorderCompound (substance)Stereochemistry

Compounds of Formula I or Formula II wherein R1, X and Ar are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.

Positive modulators of nicotinic acetylcholine receptors

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Owner:ASTRAZENECA AB

Preparation of functionalized anionic polymerization initiators

InactiveUS20060036050A1Improve stabilityAvoid the needSilicon organic compoundsLithium organic compoundsOrganolithium compoundsCompound (substance)

A process for preparing a functionalized polymerization initiator, the process comprising combining a functionalized styryl compound and an organolithium compound.

Preparation of functionalized anionic polymerization initiators

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Owner:BRIDGESTONE CORP

New compounds

InactiveUS20100256188A1More efficaciousToxic reductionBiocideNervous disorderMedicine

The present invention relates to compounds of general formula Iin which A, L, M, Q2, Q3, Q4, R1, R5, Ra, Rb, Rc, W, X, Y, Z1, Z2, Z3 are defined in the description, the salts thereof, particularly the physiologically acceptable salts thereof.The compounds are of potential utility in the treatment and / or prevention of inflammatory diseases and associated conditions, in particular, in the treatment and / or prevention of pain.The invention also relates to the use of such compounds as medicaments, to pharmaceutical compositions containing them, and to their preparation.

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Owner:BOEHRINGER INGELHEIM INT GMBH

Bis-aromatic compounds useful in the treatment of inflammation

InactiveUS20100286215A1More efficaciousToxic reductionBiocideSenses disorderDiseaseMedicine

There is provided compounds of formula (I): wherein Y, ring A, D1, D2, D3, L1, Y1, L2, Y2, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and / or required, and particularly in the treatment of a respiratory disorder and / or inflammation.

Bis-aromatic compounds useful in the treatment of inflammation

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Owner:BIOLIPOX AB

Lipid Compounds Targeting VLA-4

InactiveUS20130079383A1Reduce deliveryInhibit expressionOrganic chemistryOrganic compound preparationMedicinal chemistryNucleic acid

The invention relates to the compounds of formula I:and pharmaceutically acceptable salts and esters thereof, wherein n, G, W, X, Y, and R1 are defined in the detailed description and claims. The compounds of formula I bind to or associate with VLA-4 and can be used in delivery formulations to deliver drugs, nucleic acids, or other therapeutic compounds to tissues or cells expressing VLA-4.

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Owner:ARROWHEAD RES CORP

1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents

InactiveUS20110312935A1Reduce formationMore efficaciousBiocideSenses disorderDiseasePharmaceutical medicine

There are provided compounds of formula (I), wherein R1, R6, R8, Q2, Q3, Q3a, Q4, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and / or required, and particularly in the treatment of inflammation and / or cancer.

1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents

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Owner:OREXO AB

Preparation of functionalized anionic polymerization initiators

InactiveUS7405262B2Highly stabilized carbon-lithium siteAvoid the needSilicon organic compoundsLithium organic compoundsOrganolithium compoundsOrganic chemistry

A process for preparing a functionalized polymerization initiator, the process comprising combining a functionalized styryl compound and an organolithium compound.

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Owner:BRIDGESTONE CORP

Biodegradable targetable microparticle delivery system

InactiveUS20050163745A1Easy to packSuitable propertyOrganic active ingredientsDrug compositionsAntigenPolyester

Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligands are described. The copolymers are polyesters composed of α-hydroxy acid subunits such as D,L-lactide and pseudo-α-amino acid subunits which may be derived from serine or terpolymers of D,L-lactide and glycolide and pseudo-α-amino acid subunits which may be derived from serine. Stable vaccine preparations useful as delayed release formulations containing antigen or antigens and adjuvants encapsulated within or physically mixed with polymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody and protective responses.

Biodegradable targetable microparticle delivery system

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Owner:SOKOLL KENNETH K +2

Methods of treating inflammation

InactiveUS20090105281A1Increase therapeutic indexReduction and/or alleviationBiocideOrganic active ingredientsRelated disorderInflammation

The invention features compositions and methods for treating inflammation and other immune-related disorders.

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Owner:UNIV OF CONNECTICUT

Bis-aryl compounds for use as medicaments

InactiveUS20110071197A1More efficaciousToxic reductionBiocideSenses disorderArylMedicine

There is provided compounds of formula I, wherein ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and / or required, and particularly in the treatment of a respiratory disorder and / or inflammation.

Bis-aryl compounds for use as medicaments

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Owner:BIOLIPOX AB

Pyrazoles Useful in the Treatment of Inflammation

InactiveUS20090143455A1Improve oral bioavailabilityReduce gapBiocideOrganic active ingredientsDiseaseLipoxygenase activity

There is provided compounds of formula I,wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and / or required, and particularly in the treatment of inflammation.

Pyrazoles Useful in the Treatment of Inflammation

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Owner:BIOLIPOX AB

Comb polymer derivatives of polyetheramines useful as agricultural dispersants

ActiveUS8247353B2Low costEasy to manufactureBiocideAntifouling/underwater paintsWater insolubleWater soluble

This invention concerns novel dispersants that are the reaction products of succinic anhydride-containing resins with certain amines. These water soluble dispersants have been found to be unique and highly effective dispersants for water insoluble agricultural suspension concentrate formulations.

Comb polymer derivatives of polyetheramines useful as agricultural dispersants

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Owner:INDORAMA VENTURES OXIDES LLC

N-myristoyl transferase inhibitors

ActiveUS9156811B2Improve permeabilityRapid onset of activityBiocideAntimycoticsN-myristoyltransferaseBiochemistry

The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.

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Owner:UNIVERSITY OF DUNDEE

Novel screening method

InactiveUS20070077607A1Maintain functionPrevent extensive cell deathMicrobiological testing/measurementBiological material analysisLead compoundDrug

The present invention provides a method for identifying a drug-like compound, or lead compound for the development of a drug-like compound, which is capable of modulating cellular adhesion and / or cell survival comprising the step of testing said compound for an ability to modulate the binding of a complex of tissue transglutaminase and fibronectin to a heparan sulfate containing receptor. In particular, there is provided a method for identifying a compound for use in the curative and / or prophylactic treatment of a proliferative disorder or with efficacy in promoting wound healing and / or cell survival, and compounds identified by such methods.