30results about How to "Improve delivery" patented technology

The present invention relates to delivery of biologically active molecules to cells. Specifically, the invention relates to polycationic compositions, polymers and methods for delivering nucleic acids, polynucleotides, and oligonucleotides such RNA, DNA and analogs thereof, including short interfering RNA (siRNA), ribozymes, and antisense, or peptides, polypeptides, proteins, antibodies, hormones and small molecules, to cells by facilitating transport across cellular membranes epithelial tissues and endothelial tissues. The compositions and methods of the invention are useful in therapeutic, research, and diagnostic applications that rely upon the efficient transfer of biologically active molecules into cells, tissues, and organs.

This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including galactosamine and N-acetyl galactosamine derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones, nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.

Nasal dilators and strips, methods of their manufacture, and methods for improving the breathing of individuals are provided. The strips and dilators include an elongated substrate, with or without a dilating component or portion, having top and bottom surfaces and a pressure-sensitive adhesive disposed on the bottom surface. The dilator is designed to provide a gentle expanding force to the nasal wall tissue when the dilator is adhesively attached to the nose. This invention further includes a cosmetic fragrance, an aromatic medication and/or transdermal medication disposed on the strips or dilators. In order to improve the shelf-life and in-use olfactory effectiveness of such products, fragrance delivery mechanisms are used. Separation of volatile oils and adhesives are also provided to minimize adhesive residue.

The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.

Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, comprising conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Techniques are provided for controlling a flow of packets in a data communications device. A first technique involves transferring packets of a particular packet flow based on an initial policy scheme, and planning a scheme change to change the initial policy scheme to a new policy scheme based on conditions within the data communications device existing while transferring the packets of the particular flow based on the initial policy scheme. The first technique further involves providing a change signal to the source of a particular packet flow (e.g., a sending host). The change signal indicates that the data communications device has planned the scheme change. Additionally, the first technique involves processing the scheme change based on either a reply signal from the source or an absence of a reply signal from the source.

Another technique involves outputting packets of a particular packet flow to a data communications device that transfers the packets of the particular packet flow based on an initial policy scheme. Additionally, the technique involves receiving, in response to the outputted packets of the particular packet flow, a change signal from the data communications device. The change signal indicates that the data communications device has planned a scheme change to change the initial policy scheme to a new policy scheme. Furthermore, the technique involves providing, to the data communications device, a reply signal that provides direction for processing the scheme change.

In a remote technical support system, a technical support controller receives an indication of a maximum number of support sessions to be serviced by a remote technician. Thereafter, the technical support controller receives a service request for a user device. The technical support controller determines if handling of the service request by the remote technician would cause the number of support sessions currently being handled by the remote technician to exceed the previously-indicated maximum number of support sessions. If not, the service request is added to a work queue for the remote technician. Each service request may be classified into categories such that only remote technicians associated with a given category can handle service requests for that category. Furthermore, the process of selecting a remote technician to handle a given service request can be completely automated or based on individual remote technicians selecting service requests from a preliminary queue.

The invention discloses an electronic commerce delivered package rechecking and sorting method. The electronic commerce delivered package rechecking and sorting method comprises the following steps that (1) commodities are sorted by a sorting staff and put into a packing machine; (2) commodity barcodes are scanned by the packing machine; (3) the barcodes scanned by the packing machine are automatically matched with commodity orders, and matched barcode order results are output; (4) the matched barcode orders are matched with order data of a data platform of a delivered-package packing machine, the matched results are output by the data platform of the delivered-package packing machine; (5) data matching is conducted on the matched results output by the data platform of the delivered-package packing machine and the matched barcode order results; (6) the data is matched, and a surface list is printed; (7) the packing machine drives equipment to conduct list posting, bag discharging and sealing; (8) packing is completed, the order is rechecked and marked, and the data is transmitted to the data platform of the delivered-package packing machine; and (9) packing is finished, and logistics sorting is conducted. According to the electronic commerce delivered package rechecking and sorting method, delivery efficiency is improved, and promotion in the respects of delivery, service and customer experience is brought for the electronic commerce enterprise.

The invention discloses a method and device for providing browsers. The method for providing the browsers includes the first step of starting the first browser for a user, and monitoring the browsing process for browsing webpages through the first browser, the second step of obtaining browsing process information of the user for browsing the webpages through the first browser, and the third step of judging whether the browsing process information triggers preset triggering conditions or not, and providing relevant information of the second browser for the user if the browsing process information triggers the preset triggering conditions. Through the method, the relevant information of the second browser can be provided for the user according to the defects existing in the browsing process when the user uses the first browser. The user can install the second browser according to the relevant information of the second browser, and therefore the more convenient browser providing method is provided.

The invention discloses a system and a method for flight route planning of a logistics UAV (unmanned aerial vehicle) on the basis of a grid map. A data storage module is used for storing existing gridmap data; a master control module is used for acquiring location information of a departure point and a destination of the UAV, reading the grid map data in the data storage module, performing UAV flight route planning according to the location information of the departure point and the destination and the grid map data, and sending planned flight route information to a flight control module; a GPS (global positioning system) module is used for realizing accurate positioning of the UAV; the flight control module adopts GPS for controlling the UAV to fly along the planned flight route for logistics distribution or transceiving. According to the system and the method, the flight route of the logistics UAV is rapidly planned according to the existing grid map data, and the logistics UAV canarrive in any place along the planned flight route for logistics distribution or transceiving.

The invention discloses an underground passage for unmanned automatic freight transportation. An automatic driving area is formed in the underground passage. A mode conversion area is arranged at theend of the underground passage and is used for separating an artificial driving area from the automatic driving area. The mode conversion area includes a pedestrian zone and lanes arranged at both sides of the pedestrian zone; isolation facilities are arranged between the pedestrian zone and the lanes at the two sides; and isolation facilities are also arranged between the pedestrian zone and theautomatic driving area. A staff passage is set between the pedestrian zone and the artificial driving area. A plurality of parking spaces are arranged at the lanes at two sides of the pedestrian zone;and shielding doors matching the parking spaces are arranged in the isolation facilities between the pedestrian zone and the lanes at the two sides. According to the invention, the dual-mode transportation system combining automatic driving with manual driving is put forward; switching between the automatic driving and manual driving is realized by setting the mode switching area; and the high-efficiency transportation of automatic driving is realized by using the underground dedicated passage.

The invention relates to a non-oxidizing normalizing process of a steel pipe. The non-oxidizing normalizing process of the steel pipe is characterized by comprising the following steps of S1, pretreatment which comprises the following sub-steps of S11, preheating and heating; and S12, heat preserving, specifically, a conveying mechanism continues to convey the steel pipe forwards to a heat preserving area, the heat preserving temperature is 850-900 DEG C, and the heat preserving time is 6-8 min; S2, air cooling, specifically, nitrogen is fed into an air cooling area through a nitrogen station,the nitrogen is used as media, and used for fast cooling the steel pipe, and the steel pipe is cooled to 350-400 DEG C within the time of 1.5-2 min; S3, water cooling, specifically, a water cooling area is divided into three segments, the temperature rebounding of the steel pipe is 150-200 DEG C in the first segment of the water cooling area, that is, the temperature of the steel pipe is made tobe 500-600 DEG ; and in the first segment of the water cooling area and the second segment of the water cooling area, the steel pipe is gradually cooled to be 200 DEG C or below; and S4, discharging out of a furnace, air cooling is performed till a room temperature is achieved. The invention further discloses a device used for the non-oxidizing normalizing process of the steel pipe. Due to the non-oxidizing normalizing process of the steel pipe, the cooling speed is effectively controlled, the ideal hardness, organization and surface quality are achieved, cost is lowered, and the on-time delivery rate is increased.

The invention relates to compositions containing compounds of formula I:

and pharmaceutically acceptable salts thereof, wherein R, R¹, R², R³, and n are defined in the detailed description and claims. In addition, the present invention relates to novel formulations containing compounds of formula I for improved delivery of nucleic acids such as siRNA to the cytoplasm of target cells. In particular embodiments these formulations comprise compounds of formula I, phospholipids, cholesterol, and pegylated lipids. The present invention also relates to methods of manufacturing and using such compounds and compositions.

A method and system for delivering audio directions to a portable handheld wireless communications device. A portable handheld device can be configured to receive and play data audio files, such as, for example, MP3 audio files. Thereafter, a processor or third party service provider can generate a set of travel plans based on the location of the portable handheld device and the desired destination. The travel plan(s) can be delivered to the portable handheld device as a data audio file, which can then be played through the portable handheld device, thereby providing audio instructions that are related to the set of travel plans.

The invention discloses a function display method and system based on an electric vehicle power meter, and relates to the technical field of driving information display. The method adopts a display mode of numerical indication and a percentage model, a main interface module comprises a central information display area, an output power meter and a speedometer, interface display elements are symmetrical, and the recognition degree is high; the main interface is high in information replaceability and suitable for sharing a platform with a fuel vehicle, the platform borrowing degree is high, energy recovery is reflected through a green model and fonts, an energy flow interface does not need to be repeatedly displayed any more, the main interface is low in use rate, the energy flow interface isomitted, the information providing mode can be optimized, the interaction level of user experience (UE) is reduced, the power meter and the motor power percentage display mode are visual and novel, and based on output power and power percentage signals, the signals can be displayed in the main display interface in an energy quantification mode, and convenience is provided for data checking in theproduction and after-sales process.

The invention provides a laundry cleaning and/or care composition comprising, separately, a photo-bleach which is not a pro-fragrance (and which is preferably a singlet oxygen photo-bleach) and a pro-fragrance which is not itself a photo-bleach. The pro-fragrance preferably comprises at least one, non-aromatic, C—C double-bond, more preferably at least two C—C double-bonds, and can be advantageously be a commonplace lipid, more preferably a plant-oil. Suitable photo-bleaches comprise water-soluble phthalocyanine compounds. Preferably, the composition further comprises a shading dye to give an overall blue or violet hue to articles laundered, an optional fluorescer and/or a fabric-substantive polymer as a perfume deposition aid. Also disclosed is a method of laundering fabrics using said composition and the use of said composition to perfume fabrics.

The use of phonophoresis or iontophoresis to enhance transdermal delivery of medicinal Cetylated fatty esters when applied in cream or gel compositions is disclosed. These compositions provide hydrophilic salt forms and penetration-enhancing vehicles that work in conjunction with phonophoresis or iontophoresis to increase the efficacy of the medicinal actives.

The invention discloses a band-gap reference voltage source capable of improving an upper limit of power supply voltage fluctuation. The band-gap reference voltage source comprises an MOS transistor M1, an MOS transistor M2, an MOS transistor M3, an MOS transistor M4, an MOS transistor M5, an MOS transistor M6, an MOS transistor M7, an MOS transistor M8, an MOS transistor M9, an MOS transistor M10, an MOS transistor M11, an MOS transistor M12, an MOS transistor M13, an MOS transistor M14, a triode Q1, a triode Q2, a triode Q3, a triode Q4, a triode Q5, a resistor R1 and a resistor R2. A three-stage cascode current mirror technology is adopted, and furthermore, a gate bias supply method is improved, so that the power supply voltage range supported by a band-gap reference circuit is expandedto the maximum extent, the service life of the circuit is greatly prolonged, the service environment of the circuit is expanded and the circuit can be flexibly integrated into various integrated circuit chips.

The invention provides a method for controlling a delivery channel based on monitoring of delivery efficiency. The registration conversion rate of each delivery channel is monitored; to describe the expectation of the delivery effect of each delivery channel by referring to the registration rate; thus, the registration conversion rate and the reference registration rate are combined; whether eachthrowing channel reaches an expected throwing effect or not can be monitored. The reference registration rates are set for the different delivery channels respectively, so that the delivery efficiencycan be used as a unified standard for evaluating the delivery effect of each delivery channel, the delivery channel of the target application can be controlled according to the delivery efficiency ofeach delivery channel, and the delivery effect is improved.

This document relates to methods and materials involved in delivering molecules to a mammal. For example, methods and materials for using nanoparticles to increase the half-life and the bioavailability of molecules administered to a mammal are provided.

Dentifrice compositions comprising zinc lactate, glycine, and fluoride ion are provided for treating dental plaque biofilm.

The invention discloses a media advertisement putting system based on vehicle identification and a control method thereof. The media advertisement putting system comprises a vehicle identification device, a putting device, an outdoor playing device and a cloud server, wherein the vehicle identification device is used for identifying the vehicle information; the vehicle identification device is connected with the outdoor playing device; the outdoor playing device is arranged on the roadside and is used for playing specified media information; the outdoor playing device is connected with the cloud server and performs data communication with the cloud server; the cloud server provides media information for the outdoor playing device, wherein the vehicle identification device identifies vehicle information of a vehicle parked in a propagation area of the outdoor playing device, the vehicle identification device further comprises an analysis unit, and the analysis unit matches interest fields of personnel according to the vehicle information; the analysis unit acquires the field of interest of personnel and outputs the field of interest to the outdoor playing device; the outdoor playingdevice plays the media information matched with the field of interest of the personnel to the vehicle.

The invention belongs to the technical field of speed changers and particularly relates to an impact-resistant speed changer based on a volute spiral spring. The impact-resistant speed changer comprises a first shell body, an input shaft, a connection mechanism, an output shaft, a one-way clutch ring, a first shaft, a gear ring, the volute spiral spring and the like. By using the volute spiral spring in the connection mechanism to realize variable speed drive, the speed changer has the beneficial effects that the effect of variable speed is realized through a simple structure; and meanwhile, due to the fact that the pull force provided by the volute spiral spring is continuous, physical impact damage cannot be generated at the moment of gear shifting and speed changing, and in this way, the service life of the speed changer is greatly prolonged. A gear is made to rotate automatically through meshing of a drive tapered tooth and other tapered teeth, and transfer of large torque is realized; and besides, the gear is made to perform revolution around the gear ring under the gear shifting and speed increasing effect of the connection structure, and transfer of a large rotation speed isrealized under the dual effect of automatic rotation and revolution of the gear. The impact-resistant speed changer is simple in structure and has a good use effect.

The invention relates to a packaging mistake-proofing device and method. The device comprises more than one group of card reading units, each card reading unit comprises a card reader and a card which is uniquely matched with the card reader; meanwhile, the card reader is respectively connected with a control unit and a discharging actuating device, and the discharging actuating device is arranged on a storage bin which is uniquely matched with the card. The method comprises the following steps of: reading information of the card matched with the card reader corresponding to the designated storage bin by the card reader after the control unit generates a shipping instruction signal for the designated storage bin, outputting a discharging signal, comparing the shipping instruction signal and the discharging signal, if the two signals are matched, carrying out discharging operation by the discharging actuating device, otherwise, not starting the discharging actuating device if the two signals are not matched. By adopting the packaging mistake-proof device and method provided by the invention, faulty operation in a shipping and discharging process of an enterprise for producing black carbon can be effectively prevented, and the shipping and discharging operational efficiency can be improved.

The invention discloses a logistics information identification method and a device, a computer device and a storage medium. The method comprises the steps of obtaining waybill information of logistics, performing dual segmentation on the waybill information according to a standard word segmentation algorithm and a conditional random field lexical word segmentation algorithm; obtaining a segmentation position of the waybill information; according to a conditional random field lexical word segmentation algorithm, performing part-of-speech tagging on the waybill information; obtaining part-of-speech classification series of the waybill information; according to a logic determination algorithm, obtaining a logic judgment value of the waybill information relative to a preset template; analyzingthe waybill information according to the segmentation position, the part-of-speech analysis column and the logic judgment value; according to the method and the device, the problem of low logistics information identification accuracy is solved, the logistics waybill information identification degree is improved, the cargo distribution and receipt auditing efficiency is improved, and meanwhile, data support can be provided for later logistics service and business development planning.

The invention belongs to the technical field of stereo garages, in particular to a tree-like lifting rotary type stereo garage. The stereo garage comprises a supporting frame, a parking frame, a firstdriving source, a lifting rotary table, a second driving source and a supporting arm, wherein the supporting frame is provided with first, second, third, and fourth side frames; the parking frame isarranged on the first side frame and the second side frame, and a vehicle carrying plate is arranged on the parking frame; the lifting rotary table is movably arranged on the third side frame, and thesecond driving source is arranged on the lifting rotary table; the second driving source can drive the supporting arm to rotate to be parallel to the end part of the vehicle carrying plate, and whenthe first driving source drives the lifting rotary table to rise, the supporting arm is inserted and arranged into a supporting groove at the end part of the vehicle carrying plate. According to the tree-like lifting rotary type stereo garage, the lifting rotary table is arranged at the adjacent side part of the parking frame and is used for transferring cars, individual vacancies do not need to be arranged to realize vehicle exit, and when parking and garage leaving are carried out, the other vehicles which do not leave garages do not need to be moved, so that the process of garage leaving ofthe vehicles is reduced.