Microplate assembly and closure

a microplate and assembly technology, applied in the field of sample handling and storage assembly, can solve the problems of increasing cross contamination between wells, manual labor, and many applications, and achieve the effect of quick and easy application

Inactive Publication Date: 2003-11-11
WHEATON INDS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

Therefore and object of the present invention is to provide a microplate assembly with a closure

Problems solved by technology

Despite improvements in sample handling equipment, many applications require manual labor when performing evolutions such as preparing sample containers or vials, or covering or uncovering the samples.
This is especially the case when sample numbers are insufficient to justify design and building of custom automated equipment.
One of the problems arising from this technique is cross contamination of samples due to the

Method used

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  • Microplate assembly and closure
  • Microplate assembly and closure
  • Microplate assembly and closure

Examples

Experimental program
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Embodiment Construction

The following is a description of the preferred embodiments of a microplate assembly with closure that provides for sealing and sampling a plurality of sample vials in the microplate.

FIG. 1 is a perspective drawing of embodiment 100 of the microplate assembly with closure. Microplate 101 comprises a plurality of wells 103 arranged in a geometric pattern. In the preferred embodiment, the geometric pattern is a rectangular array eight wells in width and 12 wells in length. In the preferred embodiment, wells 103 are 6.2 millimeters in diameter (nominal dimensions) and the spacing of wells 103 in the length and width directions is 9 millimeters. In other embodiments, microplates of different numbers of wells or geometric patterns of wells are used. In the preferred embodiment, microplate 101 is made of a plastic material such as polyethylene or polypropylene. In other embodiments, microplate 101 is made of metal, composites, or glass. Microplate 101 may be machined, die cast or injectio...

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Abstract

A microplate assembly with closure comprises a microplate base 101 having a geometric array of wells 103. Vials 113 of borosilicate glass inserted into the wells comprise flanges on the top portion of the vials. Closure 117 comprises an array of caps 119 having a complementary geometric pattern to the wells of the microplate base. The caps each comprises a septum and are connected by a thin membrane 121. Each cap comprises a sidewall 403 having a vial engagement ring which snaps over the flange 115 of the vials. Septum openings 135 in the caps extend through the top of the caps and provide a means to fill and evacuate the vials with a penetration device passing through the septa of the caps of the closure.

Description

BACKGROUND OF THE INVENTIONThe present invention relates to sample handling and storing assemblies and, more particularly, to microplate assemblies.The growth in medical and pharmaceutical research as well as diagnostic analysis and testing has created a need for equipment and procedures for low cost, efficient handing of samples. Automated equipment is available for filling and retrieval of samples from sample containers.Microplates comprising a plurality of sample wells have provided a convenient means to store samples. Automated equipment is available to position microplates for sample filling, retrieving, and analysis. Despite improvements in sample handling equipment, many applications require manual labor when performing evolutions such as preparing sample containers or vials, or covering or uncovering the samples. This is especially the case when sample numbers are insufficient to justify design and building of custom automated equipment.Normally the wells of microplates are ...

Claims

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Application Information

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IPC IPC(8): B01L3/00B01L3/14
CPCB01L3/50825B01L3/50853B01L2300/042B01L2300/044B01L2300/0829
Inventor GAMBLE, KIMBERLY R.
Owner WHEATON INDS
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