The invention discloses application of a
mahonia bealei extract serving a unique
active ingredient in preparation of a medicament capable of treating chronic
inflammation wounds, wherein the chronic
inflammation wounds include wounds caused by any one of
chronic mastitis, diabetic feet, burnt wounds, chronic ulcer and
Crohn disease. The
mahonia bealei extract can be prepared into a tablet, a
capsule, an injection, an externally-applied solution,
lotion, a
liniment, an
enema, an ointment, a paste, a patch, a slow
release agent or a
controlled release agent by use of a medically acceptable carrier or
excipient. A preparation method of the
mahonia bealei extract comprises the following steps of: extracting
plant mahonia bealei stems and leaves, which serve as raw materials, by use of water,
ethanol or aqueous alcohols, performing
filtration, performing concentration until the volume is small, and performing
freeze drying to obtain a product for later use. Compared with the prior art, the
mahonia bealei extract has the beneficial effects that (1) the medicament preparation process is simple and the operation is reasonable; (2) an in-vivo external anti-
inflammation pharmacological experiment proves the application value of the
mahonia bealei extract in treating chronic inflammation wounds and provides a theoretical foundation and an experimental foundation for clinical development of the mahonia bealei extract; and (3) research on economic value of mahonia bealei has been blank, medicinal research and
drug effect research are performed, effective protection is realized on the basis of utilization, and effects of ex-situ conservation and
sustainable development can be achieved.