Compound Chinese medicine for treating child diarrhea and its preparation method

A technology for compound preparations and infantile diarrhea, which can be used in medical formulas, medical preparations containing active ingredients, and pill delivery, etc. It can solve the problems of unclear pharmacological effects, long course of treatment, and large toxic and side effects, and achieve the effect of clearing heat, detoxifying and promoting dampness , High quality controllability, little toxic and side effects

Inactive Publication Date: 2007-12-05
四川倍达尔新技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of their inherent side effects of causing kidney stones, sulfa drugs have been greatly reduced in clinical use. For children, their safety is even more questioned; Large; although the protective agent for digestive tract mucosa has good curative effect, it may cause adverse reactions such as constipation
Although the existing Chinese patent medicines for diarrhea have a certain curative effect, they often have many ingredients, the pharmacological effects are not clear, the quality and safety are not easy to control, the curative effect is not significant, the onset of effect is slow, and the course of treatment is long
For example: Xiaoer Zhixie Granules, a traditional Chinese medicine, has 12 herbs in the whole prescription, which contain more medicinal flavors, including Pueraria lobata, Scutellaria baicalensis, Atractylodes macrocephala (stir-fried), Poria cocos, woody fragrance, Magnolia officinalis officinalis, pinellia (ginger), hawthorn (burnt), zebra Diarrhea, roasted licorice, patchouli oil, berberine tannin, mainly used for children with acute and chronic diarrhea, enteritis and dysentery recovery period, can not treat children with rotavirus enteritis
Pikexin Granules, Wawa Ning Effervescent Tablets, Youxiening Granules, etc. are only used for non-sensitivity diarrhea, and Pikexin Granules contain white lentils, yam, gallinaceous gold, fried Atractylodes macrocephala, Chuan Fritillaria, woody fragrance, carbonic acid Sodium hydrogen, artificial bezoar, both Chinese and Western medicines; Wawaning effervescent tablets, containing amber, geranium, uncaria, codonopsis, fried Atractylodes macrocephala, Poria cocos, mint, fried silkworm, cinnabar, licorice, both animal medicine and minerals It is not conducive to quality control and has poor safety; Xiaoer Xiesuting Granules, a full prescription of 7 herbs, including Dijincao, catechu, Poria, hawthorn charcoal, white peony root, ebony plum, and licorice, used to treat diarrhea and abdominal pain in children , poor appetite (especially suitable for autumn diarrhea and chronic diarrhea), there are many ingredients in the prescription, the quality is not easy to control, and the curative effect is not ideal
In a word, at present, there is still no specific treatment for children with autumn diarrhea caused by rotavirus in China, and there are few Chinese patent medicines that have a good inhibitory effect on rotavirus.

Method used

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  • Compound Chinese medicine for treating child diarrhea and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Take 2 parts of Scutellaria baicalensis and pulverize it into the coarsest powder; 10 parts of Dijincao, 10 parts of Poria cocos, and 10 parts of Atractylodes macrocephala are pulverized and mixed, then add water (that is, 256 parts of water) that is 8 times the total weight of the four herbs, and boil until Boiling, put in the most coarse powder of Scutellaria baicalensis, decoct for 0.5 hours, filter the decoction; Combine the decoctions of each decoction to obtain a water extract, and concentrate the water extract to an extract with a relative density of 1.10 to 1.40; cool to room temperature, and slowly add ethanol under stirring to make the alcohol content reach 30% (volume ratio), fully stirred, left to stand for 24 hours, and the supernatant was filtered; the filter residue was washed with an appropriate amount of 30% ethanol (the amount of 30% ethanol is generally 1-5 times that of the filter residue), stirred evenly, centrifuged, Take the supernatant, combine t...

Embodiment 2

[0056] Take 10 parts of Scutellaria baicalensis and crush it into the coarsest powder; 30 parts of Dijincao, 2 parts of Poria cocos, and 2 parts of Atractylodes macrocephala are crushed and mixed, add water 15 times the total weight of the four herbs, boil until boiling, and put in the coarsest powder of Scutellaria baicalensis , decocted for 2 hours, and filtered the decoction; then decocted the dregs twice, adding 15 times of water each time, decocted for 2 hours, filtered the decoction; combined the decoctions of each decoction, The water extract is obtained, and the water extract is concentrated to an extract with a relative density of 1.10-1.40. Cool to room temperature, slowly add ethanol under stirring to make the alcohol content reach 60%, stir well, let stand for 48 hours, and filter the supernatant. The filter residue is washed with an appropriate amount of 60% ethanol (the amount of 60% ethanol is generally 1-5 times that of the filter residue), stirred evenly, cent...

Embodiment 3

[0058] Take 2 parts of Scutellaria baicalensis and crush it into the coarsest powder; 30 parts of Dijincao, 10 parts of Poria cocos, and 10 parts of Atractylodes macrocephala are crushed and mixed, add water 12 times the total weight of the four herbs, boil until boiling, and put in the coarsest powder of Scutellaria baicalensis , decoct for 1 hour, filter the decoction; then decoct the dregs of the medicine once more, add 12 times of water when decocting, decoct for 2 hours, and filter the decoction. Combining the decoctions for each decoction to obtain a water extract, and concentrating the water extract to an extract with a relative density of 1.10-1.40. Cool to room temperature, slowly add ethanol under stirring to make the alcohol content reach 80%, stir well, let stand for 48 hours, and filter the supernatant. The filter residue is washed with an appropriate amount of 80% ethanol (the amount of 80% ethanol is generally 1-5 times that of the filter residue), stirred evenl...

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Abstract

A Chinese medicine for treating infantile diarrhea is prepared from Japanese creeper, scutellaria root, tuckahoe, and ahite atractylodes rhizome.

Description

Technical field [0001] The invention relates to a compound traditional Chinese medicine preparation for treating diarrhea, in particular to a Chinese patent medicine mainly used for treating acute and chronic diarrhea in children. Background technique [0002] Diarrhea in children is a group of diseases mainly caused by multiple pathogens and factors. Due to the special physiological characteristics of children, diarrhea is a common and frequently-occurring disease in children under the age of 14. For children under the age of 5, the incidence of the disease is second only to respiratory tract infection. Among the medicines currently clinically used to treat diarrhea, western medicine mainly includes sulfonamides, antibiotics and digestive tract mucosal protective agents. Because of their inherent side effects of causing kidney stones, sulfa drugs have been greatly reduced in clinical use. For children, their safety is even more questioned; Large; although the protective a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/539A61K36/47A61K36/284A61K36/076A61K9/00A61K9/20A61K9/48A61K9/16A61K9/08A61K9/10A61K9/19A61P1/12
Inventor 王兴文任昉李萍梁仁兴
Owner 四川倍达尔新技术开发有限公司
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