Medicine for treating acute and chronic cholecystitis and cholelithiasis, process for preparing the same and application thereof

A cholecystitis, acute and chronic technology, applied in the treatment of acute and chronic cholecystitis, cholelithiasis drugs, the preparation of the drug can solve the problem of difficult extraction and retention of active ingredients, to maintain natural characteristics, less components, no Effects of Solvent Residue Toxicity

Inactive Publication Date: 2008-01-02
SHENZHEN DONGFANG TAIGE BIOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, pure traditional Chinese medicine preparations are used in the treatment of acute and chronic cholecystitis and cholelithiasis. The most common methods are water decoction and water extraction and alcohol precipitation. It is difficult to retain the volatile parts or water-soluble parts, that is to say, it is difficult to extract and retain the active ingredients in the raw materials to the greatest extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 drug soft capsule

[0038] Wash Cyperus cyperi and dried ginger with clean water, dry at a low temperature of 50°C, grind the dried Cyperus cyperi and dried ginger to 20 mesh fine powder; separate the crushed Cyperus cyperi and dried ginger Adopting the supercritical carbon dioxide fluid extraction device of 100ml-SPE manufactured by Hanwei (HANDWAY) company to extract effective active substances, wherein the extraction temperature of Cyperus cyperi powder is 49.5°C, the extraction pressure is 21mPa, and the extraction time is 2 hours; dry ginger powder The extraction temperature is 35°C, the extraction pressure is 25mPa, and the extraction time is 4.5 hours. The supercritical extract of Cyperus cyperi was further refined by a molecular distillation device, the injection speed was 1000g / h, the distillation temperature was 80°C, and the fraction with high volatile oil content was taken as Cyperus cyperi extract. After mixing 25% by weight...

Embodiment 2

[0039] The preparation of embodiment 2 medicine soft capsules

[0040] Clean Cyperus cyperi and dried ginger respectively with clean water, dry at 40°C in a low temperature state, crush the dried Cyperus cyperi and dried ginger to 20 mesh fine powder; Adopting the supercritical carbon dioxide fluid extraction device of 100ml-SPE manufactured by Hanwei (HANDWAY) company to extract effective active substances, wherein the extraction temperature of Cyperus cyperi powder is 45°C, extraction pressure is 25mPa, and extraction time is 1.5 hours; dry ginger powder The extraction temperature is 38°C, the extraction pressure is 29mPa, and the extraction time is 3.5 hours. The supercritical extract of Cyperus cyperi was further refined by a molecular distillation device, the injection speed was 1200g / h, the distillation temperature was 100°C, and the fraction with high volatile oil content was taken as Cyperus cyperi extract. After mixing 75% by weight of Rhizoma Cyperi extract and 25% ...

Embodiment 3

[0041] The preparation of embodiment 3 medicine soft capsules

[0042] Clean Cyperus Cyperi and Dried Ginger with clean water respectively, dry Cyperus Cyperi and Dried Ginger at a low temperature of 55°C, pulverize the dried Cyperus Cyperi and Dried Ginger to 20 mesh fine powder, and grind the Cyperus powder and dried ginger powder were extracted with 100ml-SPE supercritical carbon dioxide fluid extraction device manufactured by Hanwei (HANDWAY) company to extract effective active substances, wherein the extraction temperature of Cyperus powder was 52°C, the extraction pressure was 21mPa, and the extraction time It was 2.1 hours; the extraction temperature of dried ginger powder was 36°C, the extraction pressure was 26mPa, and the extraction time was 4 hours. The supercritical extract of Cyperus cyperi was further refined by a molecular distillation device, the injection speed was 900g / h, the distillation temperature was 100°C, and the fraction with high volatile oil content ...

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating acute and chronic cholecystitis and gall stone, and process for preparation, wherein the composition comprises the following constituents (by weight portions), cyperus tuber extract 20-80% and dried ginger 20-80%.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a Chinese patent medicine prepared from Chinese herbal medicines for treating acute and chronic cholecystitis and cholelithiasis. The invention also relates to a preparation method and application of the medicine. Background technique [0002] Cholelithiasis is a common disease of the biliary system, accounting for about 60% of its incidence. It is closely related to bile duct congenital abnormalities, infection, injury and other diseases. Modern medicine can be divided into gallbladder stones, extrahepatic bile duct stones and intrahepatic bile duct stones according to the location of the stones; according to the ingredients contained in the gallstones, they can be divided into cholesterol stones, pigment stones and mixed stones. Cholelithiasis belongs to the category of gallbladder distension, chest yellowing, hypochondriac pain, liver distension, depression, jaundi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K36/8905A61K9/48A61P1/16
Inventor 冯毅凡蔡健聪
Owner SHENZHEN DONGFANG TAIGE BIOPHARML
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