Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Self-diffusion in water type chemicals for preventing and killing blood fluke, and its preparation method

A water surface diffusing agent and pharmaceutical preparation technology, applied in botany equipment and methods, animal repellants, plant growth regulators, etc., can solve problems such as difficult to achieve targeted drug delivery, difficult to control, etc., and achieve simple preparation methods , Ease of use

Inactive Publication Date: 2008-07-09
范小林 +1
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since more than 98% of schistosomiasis cercariae float on the water surface in a static manner and can float with the waves, it is difficult to control them with conventional chemicals
Oncomelania, the intermediate host of schistosomiasis, usually also inhabits near the water surface, it is difficult to achieve the purpose of targeted drug delivery by using conventional methods

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0006] Add 43 parts of kerosene and 30 parts of cyclohexane into the reaction kettle successively, stir at room temperature for 20 minutes, control the stirring speed at 100-500 rpm, wait for uniform dispersion, and let it stand still. Then add 15 parts of praziquantel, and after it is completely dissolved, add 6.5 parts of polyoxyethylene laurate, 1.5 parts of Span-20, 0.5 parts of sodium lauryl sulfate, 2 parts of ethylene glycol, and hydroxymethyl cellulose 1.5 parts, stirring speed is 500-1000 rpm, pressure 0.1-0.2MPa, stirring for 30 minutes. Adjust the PH value between 7-8, adjust the surface tension, so that the outflow rate of the medicine from the pipette is not lower than 60 drops / min, let it stand for 1 hour, and then continue to stir for 30 minutes, filter and pack.

Embodiment 2

[0008] Put 50 parts of xylene and 10 parts of rapeseed oil into the reaction kettle successively, stir at room temperature for 25 minutes, control the stirring speed at 300-500 rpm, and after the dispersion is uniform, add 30 parts of hexachloro-p-xylene, wait After all of them are dissolved, add 0.5 parts of OP-10, 0.5 parts of fatty amine polyoxyethylene ether, 5 parts of n-butanol, 2 parts of diethyl ether, 2 parts of butyl acetate, and 0.1 part of polyethylene glycol. The stirring speed is 500-600 rpm, pressure 0.1-0.3MPa, stirring for 30 minutes, adjust the pH value between 6-8. Adjust the surface tension so that the outflow rate of the medicine from the pipette is not lower than 60 drops / min, let it stand for 1 hour, then continue to stir for 30 minutes, filter and pack.

Embodiment 3

[0010] Add 60 parts of cyclohexane and 35 parts of xylene into the reaction kettle successively, stir evenly, and control the stirring speed to 500-600 rpm. Then add 3 parts of N-trityl morpholine, after it is completely dissolved, heat up to 60°C, add 1 part of fatty alcohol polyoxyethylene ether, 0.1 part of OP-100, 0.3 part of ether, 0.6 part of hexanediol, 2.0 parts of carmellose, stirred for 45 minutes, the stirring speed was controlled at 1000-2000 rpm, the pressure was 0.5-0.6MPa, and the pH value was adjusted between 7-8. Adjust the surface tension so that the outflow rate of the medicine from the pipette is not lower than 60 drops / min, let stand for a while, stir continuously for 40 minutes, filter, and dispense.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A drug able to automatically diffuse on water surface for preventing and treating the blood fluke is prepared from active drug (1-30 wt.%), liquid carrier (60-95),diffusing agent(0.1-10),diffusing aid(0.1-5) and stabilizer (0.1-5) through stirring, and regulating pH value, water content and surface tension.

Description

technical field [0001] The invention discloses a water surface self-diffusion type medicinal preparation for preventing and treating schistosomiasis and a preparation method thereof. The preparation method of the medicinal preparation is simple and convenient to use. When applying the drug, you only need to drop the drug into the water surface according to the dosage, and the drug molecules can quickly and automatically diffuse on the water surface and form a nano-scale film of drug molecules. Once the drug molecule film is formed, it can float on the water surface for a long time under the action of surface tension. The medicinal preparation is suitable for both manual spraying and large-area aircraft spraying, and is especially suitable for the prevention and treatment of schistosomiasis in deep water areas or floods. Background technique [0002] In the traditional prevention and treatment of schistosomiasis, people often use wettable powder, powder, granule, suspension ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A01N25/00
Inventor 范小林龚子方范文峰
Owner 范小林
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com