Technique for preparing injection of protein polyeptide

A technology of protein polypeptide and preparation process, which is applied in the field of preparation process of protein polypeptide injection, to achieve the effects of controlling product quality, high production pass rate, and no toxic and side effects

Inactive Publication Date: 2008-10-15
吉学文
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the production process of Haimain has not been made public yet

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] Production of protein and polypeptide injections according to the requirements of the technical plan:

[0015] 1. Dissolving: dissolving bovine bone, pork bone or other gelatin with hot water for injection;

[0016] 2. Acid degradation or enzymatic hydrolysis: adjust the pH value of beef bone, pork bone or other gelatin aqueous solution between 5.0-6.0, raise the temperature to 110°C-120°C, keep this temperature, measure the weight average molecular weight every 5 minutes, When the molecular weight reaches 10000-12500, stop heating and cool down rapidly to 25°C-35°C;

[0017] 3. Cross-linking: adjust the pH value of the degradation solution to 10.6-12.4, maintain the temperature at 25°C-35°C, add a cross-linking agent with a gelatin protein polypeptide content of 0.3%-7%, stir for 4-6 hours, and measure its weight The average molecular weight is 27500-39500.

[0018] 4. Drying: The cross-linked protein polypeptide hydrolyzate is heated and dried to make powder.

[00...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A protein polypeptide injection used as hemovolume increaser for supplementing the blood to human body is a sterilized aqueous solution prepared from ox bone or pig bone through gelatimizing and proportionally mixing it with electrolyte.

Description

technical field [0001] The invention belongs to the production process of protein polypeptide injection, in particular to the process of producing protein polypeptide injection by machine using bovine bone, pig bone or other gelatin proteins. Background technique [0002] The country is now importing a small amount of Haimain made from hydrolysis of bovine bone gelatin. It is widely used in various hospitals in China to supplement blood volume in various operations, traumatic blood loss, toxic shock, etc., instead of plasma products. At present, mad cow disease is spreading in Europe, and countries have strictly controlled the import of cattle and their products. And the production process of Haimain has not been made public yet. Compound oxidized gelatin injection was developed in my country in the 1980s, but because the product quality at that time still had a certain gap with imported products, especially in the determination of weight average molecular weight, relative...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61K9/08A61P7/08
Inventor 吉学文
Owner 吉学文
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap