Application of water-soluble multi-wall carbon nanotube as substrate in MALDI-MS

A multi-walled carbon nanotube, water-soluble technology, applied in the direction of nanotechnology, nanotechnology, nanostructure manufacturing, etc., can solve problems such as difficult to accurately control the amount of matrix added, low desorption ionization efficiency, and weak surface interaction of metal targets , to achieve the effects of convenient quantitative analysis, improved desorption ionization efficiency, and convenient sample pointing operation
CN100430724CInactive Publication Date: 2008-11-05DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Publication Date
2008-11-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention uses water-soluble multi-wall carbon nano tube as MALDI matrix for MALDI-MS, overcomes the defect of nano tube self, accelerates analysis for small molecular compound, and realizes quantitative and qualitative analysis fast and accurately.
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Description

technical field

[0001] The invention relates to a matrix material of MALDI, specifically the application of water-soluble multi-walled carbon nanotubes in MALDI-MS as a matrix of MALDI. Background technique

[0002] In 1988, Tanaka and Hillenkamp independently proposed a technology to assist analyte desorption and ionization by absorbing laser energy through a matrix, called Matrix Assisted LaserDesorption / Ionization (MALDI). Combined with time-of-flight mass spectrometry, this technology has become a powerful tool in biotechnology. It has been successfully applied to the detection of biological macromolecules such as proteins, DNA / RNA, and polysaccharides, and won the 2002 Nobel Prize in Chemistry. However, the introduction of the matrix brings a large number of matrix peaks in the low molecular weight range, resulting in serious background interference, thus limiting the application of this method in the analysis of small molecules. In addition, factors such as the choice...

Claims

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