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Application of yohimbine and berberine mixture in medicament preparation

A technology of berberine and yohimbine, which is applied in the application field of mixing yohimbine and berberine in pharmaceuticals, can solve the problems of reducing mortality, lack of prevention and treatment of enterogenic endotoxemia, etc., to improve survival rate, the effect of a wide range of application prospects

Inactive Publication Date: 2008-11-12
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, multi-center clinical studies have found that no preparation can significantly reduce mortality
On the other hand, enterogenous endotoxemia is an important pathogenic factor of severe burns and trauma complicated with multiple organ dysfunction, and there is still a lack of effective drugs for the prevention and treatment of enterogenous endotoxemia

Method used

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  • Application of yohimbine and berberine mixture in medicament preparation
  • Application of yohimbine and berberine mixture in medicament preparation
  • Application of yohimbine and berberine mixture in medicament preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] To observe the effect of combined application of berberine and yohimbine on the mortality of endotoxemia mice.

[0018] Healthy male BALB / C mice (body weight 20-25g) were randomly divided into 6 groups: the following treatments were performed respectively:

[0019] ① control group (control), figure 1 Indicated by a solid square: 3 days in advance, intraperitoneal injection of physiological saline (0.05ml / 10g), 30 minutes later intragastric administration of water (0.2ml / 10g), once a day, 1 hour after intragastric administration on the last day, intraperitoneal injection of physiological brine;

[0020] ②LPS group (LPS), figure 1 Indicated by a hollow triangle: 3 days in advance, intraperitoneal injection of normal saline (0.05ml / 10g), 30 minutes later intragastric administration of water (0.2ml / 10g), once a day, 1 hour after intragastric administration on the last day, intraperitoneal injection Toxin (LPS, 055:B5, Sigma, 20mg / kg);

[0021] ③Berberine control group [...

Embodiment 2

[0029] Effects of different doses of yohimbine combined with 50 mg / kg berberine on mortality in endotoxemic mice.

[0030] Healthy male BALB / C mice (body weight 20-25g) were randomly divided into 5 groups: the following treatments were performed respectively:

[0031] ① control group (control), figure 2 Indicated by a hollow square: 3 days in advance, intraperitoneal injection of physiological saline (0.05ml / 10g), 30 minutes later intragastric administration of water (0.2ml / 10g), once a day, 1 hour after intragastric administration on the last day, intraperitoneal injection of physiological brine;

[0032] ②LPS group (LPS), figure 2 Indicated by a hollow triangle: 3 days in advance, intraperitoneal injection of normal saline (0.05ml / 10g), 30 minutes later intragastric administration of water (0.2ml / 10g), once a day, 1 hour after intragastric administration on the last day, intraperitoneal injection Toxin (LPS, 055:B5, Sigma, 20mg / kg);

[0033] ③ 1mg / kg yohimbine and 50mg...

Embodiment 3

[0040] Effect of 2mg / kg yohimbine and 50mg / kg berberine mixed preparation (berberine and yohimbine mixture) administered orally on the mortality of endotoxemia mice.

[0041] Healthy male BALB / C mice (body weight 20-25g) were randomly divided into 4 groups: the following treatments were performed respectively:

[0042] ① Control group (control): gavage with water (0.2ml / 10g) for 3 days, once a day, and inject normal saline into the abdominal cavity 1 hour after gavage on the last day;

[0043] ②LPS group (LPS): gavage with water (0.2ml / 10g) for 3 days, once a day, and intraperitoneally inject endotoxin (LPS, 055:B5, Sigma, 20mg / kg) 1 hour after gavage on the last day;

[0044] ③ 2mg / kg yohimbine and 50mg / kg berberine mixed preparation for 3 days prevention group [berberine and yohimbine mixture (3) group]: 2mg / kg yohimbine and 50mg / kg berberine mixed preparation Stomach, once a day, for 3 days in total, 1 hour after gavage on the third day, intraperitoneally inject LPS (20mg / ...

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Abstract

The invention relates to a method for using yohimbine and berberine to prepare the drug that treats endotoxin multi-organ disturbance syndrome. The yohimbine and berberine can treat endotoxin multi-organ function reduction, to improve the survival rate of endotoxemia patient. And serious injury, burn and Gram-negative bacterium can cause sausage endotoxemia, and the inventive drug can be used auxiliary drug. The invention has wide application.

Description

technical field [0001] The invention relates to the application of yohimbine and berberine mixed preparation in pharmacy. Background technique [0002] Although the application of antibiotics and clinical treatment measures have made great progress in the past 50 years, the mortality rate of patients with sepsis is still as high as 40%-60%. Reducing the mortality rate of patients with infectious multiple organ failure is currently a medical problem. a big problem. Studies have shown that 45%-60% of sepsis is caused by Gram-negative bacterial infection, and endotoxin or lipopolysaccharide (LPS), the main component of the cell wall of Gram-negative bacteria, plays a role in the systemic inflammatory response syndrome caused by this infection (SIRS) play an important role. Therefore, finding new drugs to prevent and treat endotoxin-induced multiple organ failure is of great significance for reducing the mortality of sepsis patients. [0003] Since the 1980s, the research on ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/475A61P31/04A61P43/00A61K31/4375
Inventor 陆大祥王华东张昊晴戚仁斌
Owner JINAN UNIVERSITY
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