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Targeted nanometer medicine carrier and its prepn. method

A nano-drug carrier and targeting technology, which can be used in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problems of neglected research on sugar compounds, and achieve biodegradability, biocompatibility, and good safety , stabilizing and targeted effects

Inactive Publication Date: 2008-12-03
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on carbohydrate chemistry was earlier, but when the research on nucleic acid and protein was in its heyday, the research on carbohydrate compounds was once neglected

Method used

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  • Targeted nanometer medicine carrier and its prepn. method
  • Targeted nanometer medicine carrier and its prepn. method
  • Targeted nanometer medicine carrier and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] In the reaction flask, at room temperature, add 20 mg of sodium alginate and 24 mg of mannan, add 4 ml of 0.1 mol / L HCl, stir for 0.5 hours, and use 0.1 ml / L of NaOH to dissolve the above solution Adjust the pH value to 7; add 1 mg of ammonium persulfate and 1 mg of sodium lauryl sulfate, then raise the temperature to 60 ° C, react for 2 hours under stirring, wash with deionized water, and dry in a freeze dryer, that is Sodium alginate-mannan polymer is prepared for future use.

Embodiment 2

[0048] In the reaction flask, at room temperature, add 10 mg of sodium alginate and 20 mg of mannan, add 4 ml of 0.05 mol / L HCl, stir for 2 hours, and use 0.1 ml / L of NaOH to dissolve the above solution Adjust the pH value to 7; add 0.8 mg of ammonium persulfate and 0.8 mg of sodium lauryl sulfate, then raise the temperature to 40 ° C, react for 4 hours under stirring, wash with deionized water, and place in a freeze dryer drying in medium to prepare the sodium alginate-mannan polymer carrier for future use.

[0049] The conversion rate of the sodium alginate-mannan polymer graft polymer prepared by the above method is high, and the degree of esterification of the polymer can be adjusted by changing the concentration of mannan from 50% to 100%, and then the polymer can be changed. hydrophilicity.

[0050] The sodium alginate-mannan polymer prepared by the invention is analyzed and detected by IR, and the esterification reaction reaches 100%.

[0051] The present invention us...

Embodiment 3

[0052] Embodiment 3 adopts O / W solvent emulsification evaporation method to prepare example

[0053] In the reaction bottle, take 1 mg of sodium alginate-mannan polymer, take 5 mg of the insoluble or water-insoluble antineoplastic drug vincristine, dissolve in 5 ml of CH 2 CI 2 In 10ml aqueous solution containing the surfactant polyvinyl alcohol (PVA) of 1% by volume, slowly added dropwise to obtain the emulsion, at room temperature, stirred and reacted for 8 hours, so that the organic solvent in the emulsion evaporated, and used The nano-microspheres are collected by high-speed centrifugation in a centrifuge, and then the nano-microspheres are repeatedly washed with distilled water for more than three times to obtain a targeted nano-medicine carrier, which is placed in a lyophilizer for freeze-drying and storage for later use.

[0054] The O / W solvent emulsification evaporation method is suitable for anti-tumor drugs that are insoluble or insoluble in water. The particle siz...

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Abstract

A target medicine nano-carrier used for anti-neoplastic medicine, cancer suppressing gene and gene vaccine is prepared from sodium alginate and mannosan through polymerizing by solvent emulsifying and evaporating method, ultrasonic emulsifying method, or high-pressure emulsifying method to obtain nano-class sodium alginate-mannosan polymer.

Description

technical field [0001] The invention relates to a targeted nano drug carrier and a preparation method thereof, in particular to a novel targeted nano drug carrier of sodium alginate-mannan polymer and a preparation method thereof. Background technique [0002] In my country, about 1.3 million people die of malignant tumors every year, and the estimated incidence is between 1.8 million and 2 million, and the overall incidence is constantly rising. In many large cities in China, malignant tumors have surpassed cardiovascular and cerebrovascular diseases, ranking first among all causes of death, and in the 35-59 age group, malignant tumors have always been the number one killer. Tumor is a complex disease with multiple mechanisms. The current treatment method still adopts traditional comprehensive methods such as early diagnosis, radiotherapy, and chemotherapy. Using the above treatment method, its biggest defect is that the resolution of diseased cells and normal cells is low...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61P35/00A61K47/36
Inventor 范琳玉张恒
Owner SICHUAN UNIV
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