Cefepime halogen acid salt preparation method

A technology of hydrohalide salts and cefepime, which is applied in the field of preparation of cephalosporin compounds, can solve problems such as reducing production costs, and achieve the effects of reducing production costs, improving purity, and saving production costs
CN100457759CActive Publication Date: 2009-02-04SHENZHEN SALUBRIS PHARMA CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN SALUBRIS PHARMA CO LTD
Publication Date
2009-02-04

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Abstract

The invention relates to a method for preparing cefepime hydrohaloride. It takes sulfate of cefepime as raw material and produce cefepime hydrohaloride with barium halide. It effectively solves the corrosive problem to producing device, reduces production cost and increases product purity.
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Description

[technical field]

[0001] The invention relates to a preparation method of cephalosporin compounds, in particular to a method for preparing cefepime hydrohalide by using cefepime sulfate and barium halide as raw materials. [Background technique]

[0002] Cefepime (cefepime) is the fourth-generation cephalosporin antibiotics for injection, developed by the American Boomer-Squibb (BMS) company (US 4,406,899), and was first listed in Sweden in 1993. It entered my country in 1998 with the product name "Masipime". Cefepime has good antibacterial activity against Gram-negative bacteria (such as Enterobacter, Pseudomonas aeruginosa), Gram-positive bacteria (such as Streptococcus pneumoniae, Staphylococcus aureus) and anaerobic bacteria, and has good antibacterial activity against β- Lactamase exhibits higher stability, and has a wider antibacterial spectrum and antibacterial activity than the third-generation cephalosporin antibiotics.

[0003] Cefepime is a neutral inner salt wit...

Claims

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