Vaginal effervescence tablet of Ainsliaea fragrans and preparation method thereof

An effervescent tablet, vaginal technology, applied in the field of vaginal effervescent tablets, can solve the problems of slow onset, low blood drug concentration and the like

Inactive Publication Date: 2009-09-30
江西省药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to develop a kind of effervescent tablet preparation directly used in the vagina in order to overcome the shortcomings of low local blood drug concentration and slow onset of action in the oral preparation of apricot rabbit ear wind

Method used

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  • Vaginal effervescence tablet of Ainsliaea fragrans and preparation method thereof
  • Vaginal effervescence tablet of Ainsliaea fragrans and preparation method thereof
  • Vaginal effervescence tablet of Ainsliaea fragrans and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] (1) Preparation of Xingxiang Rabbit's Ear Wind Extract: Take Xingxiang Rabbit's Ear Wind medicinal material, wash it, add 10 times the amount of water, decoct three times, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.1 to 1.2 (60°C) clear paste, add ethanol to make the alcohol content 70%, let it stand overnight, take the supernatant together, wash the precipitate twice with 70% ethanol, combine the washing liquid and the supernatant, and recover the ethanol And concentrated into a thick paste, placed in a vacuum oven and dried under reduced pressure at low temperature to form a dry paste.

[0078] (2) Preparation of Xingxiang Rabbit Earfeng Effervescent Tablets:

[0079] Weigh raw materials according to the following prescription ratio:

[0080] Apricot rabbit ear air-dried extract 1 part

[0081] Anhydrous citric acid 0.45 parts

[0082] Sodium bicarbonate 0.45 parts

[0083] Starch 0.14 parts

[00...

Embodiment 2

[0090] (1) Preparation of Xingxiang Rabbit's Ear Wind Extract: Take Xingxiang Rabbit's Ear Wind medicinal material, wash it, add 10 times the amount of water, decoct three times, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.1 to 1.2 (60°C) clear paste, add ethanol to make the alcohol content 70%, let it stand overnight, take the supernatant together, wash the precipitate twice with 70% ethanol, combine the washing liquid and the supernatant, and recover the ethanol And concentrated into a thick paste, placed in a vacuum oven and dried under reduced pressure at low temperature to form a dry paste.

[0091] (2) Preparation of Xingxiang Rabbit Earfeng Effervescent Tablets:

[0092] Weigh raw materials according to the following prescription ratio:

[0093] Apricot rabbit ear air-dried extract 1 part

[0094] Anhydrous citric acid 0.58 parts

[0095] Sodium bicarbonate 0.58 parts

[0096] Starch 0.18 parts

[00...

Embodiment 3

[0103] (1) Preparation of Xingxiang Rabbit's Ear Wind Extract: Take Xingxiang Rabbit's Ear Wind medicinal material, wash it, add 10 times the amount of water, decoct three times, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.1 to 1.2 (60°C) clear paste, add ethanol to make the alcohol content 70%, let it stand overnight, take the supernatant together, wash the precipitate twice with 70% ethanol, combine the washing liquid and the supernatant, and recover the ethanol And concentrated into a thick paste, placed in a vacuum oven and dried under reduced pressure at low temperature to form a dry paste.

[0104] (2) Preparation of Xingxiang Rabbit Earfeng Effervescent Tablets:

[0105] Weigh raw materials according to the following prescription ratio:

[0106] Apricot rabbit ear air-dried extract 1 part

[0107] Anhydrous citric acid 0.7 parts

[0108] Sodium bicarbonate 0.7 parts

[0109] Starch 0.225 parts

[011...

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Abstract

The invention relates to a local Chinese medicine preparation for treating gynecological inflammation-Xingxiang rabbit ear wind vaginal effervescent tablet. It firstly extracts the medicinal material of apricot and rabbit's ear wind to make a dry extract, and then takes the dry extract and auxiliary materials according to a certain weight ratio of 1:1-6. Wherein the auxiliary materials are composed of effervescent excipients (acid source, carbon dioxide source), fillers, surfactants, disintegrants, lubricants and binders. The beneficial effects of the present invention are as follows: the quality standard is improved: in the research on the quality standard of the medicine of the present invention, a TLC identification method using protocatechuic aldehyde and protocatechuic acid as reference substances has been established, and a high performance liquid chromatography method has been established to determine Methods for protocatechuic acid content. Pharmacodynamic research shows that the medicine of the present invention has the effect of obviously reducing the histopathological changes of phenol-induced vaginal and uterine inflammation models in female rats; the antibacterial test in vitro shows that the medicine of the present invention is effective against beta-hemolytic streptococcus, Escherichia coli, Staphylococcus aureus Bacillus and Streptococcus pneumoniae are bacteriostatic.

Description

technical field [0001] The invention relates to a local Chinese medicine preparation for treating gynecological inflammation, in particular to a vaginal effervescent tablet made from the plant Chinese herbal medicine Xingxiang rabbit's ear wind. The invention also relates to a preparation method of the medicine. Background technique [0002] Inflammation of the female reproductive system is a common and frequently-occurring disease in gynecology. It has been reported that among the 600 million women in my country, especially 82% of married women suffer from various degrees of gynecological inflammation. Inflammation mostly occurs in the lower reproductive tract, such as vulvitis, vaginitis and cervicitis, and can also invade the upper reproductive tract, that is, the internal genitalia, causing pelvic inflammatory disease, which seriously affects the quality of life of the majority of sick women. Surveys have shown that chronic cervicitis and cervical erosion are closely r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K9/20A61K9/46A61P15/02A61P15/00
Inventor 张爱华王晖肖小华陈梅荣尧享华徐丽瑛郑国安胡丹张锐
Owner 江西省药物研究所
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