Gastric floating capsule of 'Zuo Jin Wan' and preparation method thereof

A gastric flotation and capsule technology is applied in the field of Zuojin gastric flotation capsule and its preparation, and achieves the effects of clear ingredients, high technical content and clear mechanism of action

Inactive Publication Date: 2009-12-02
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no traditional Chinese medicine gastric floating drug delivery system on the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (1) Raw material prescription: Coptidis 1284g, Evodia 214g.

[0053] (2) Extraction and refinement: take 214g of Evodia rutaecarpa medicinal material, extract the volatile oil by steam distillation for 3.0 hours; weigh β-cyclodextrin (g / ml) equivalent to 8 times the amount of volatile oil, and adopt the saturated aqueous solution method to clathrate at 60°C for 3 hours, Refrigerate, filter, dry the clathrate at low temperature, and pulverize for later use. Evodia rutaecarpa and coptis 1284g, reflux extraction with 60% ethanol for 3 times, 1 hour each time, combine extracts, recover ethanol under reduced pressure; Sodium oxide aqueous solution to neutralize sulfuric acid, add 95% medicinal ethanol to make the alcohol concentration of the medicinal solution 80%, let it stand, and filter; the filtrate recovers ethanol, vacuum-dries, pulverizes through a 100-mesh sieve, and clathrates with β-cyclodextrin of volatile oil The mixture was evenly mixed to obtain 200 g of Zuoji...

Embodiment 2

[0056] (1) Raw material prescription: Coptidis 12.84kg, Evodia 2.14kg.

[0057] (2) Preparation: Take 12.84 kg of Coptis chinensis and 2.14 kg of Evodia rutaecarpa, grind them into coarse powder, extract by percolation with 0.5% sulfuric acid aqueous solution, collect about 150 L of percolation liquid, neutralize it with 40% sodium hydroxide solution, and depressurize Concentrate to 15kg, add 95% ethanol until the ethanol concentration of the liquid medicine system is 80%, let it stand for more than 6 hours, and filter; the filtrate recovers ethanol under reduced pressure, vacuum-dries, pulverizes and passes through a 100-mesh sieve to obtain 1850 g of Zuojin extract .

[0058] (3) Preparation molding: Weigh 800g of hydroxyethyl cellulose, 200g of sodium carboxymethyl cellulose, 500g of stearic acid, 200g of stearyl alcohol, 100g of sodium bicarbonate, 350g of polyethylene glycol (PEG 6000) and Zuojin 1850g of the extract was mixed evenly, filled in hard capsules (0.4g / capsul...

Embodiment 3

[0060] (1) Ingredients: Coptidis 1284g, Evodia 214g.

[0061] (2) Preparation: take 214g of Evodia rutaecarpa medicinal material, extract the volatile oil by steam distillation for 3.0h; weigh β-cyclodextrin (g / ml) equivalent to 8 times the amount of volatile oil, adopt saturated aqueous solution method for inclusion at 60°C for 3h, and refrigerate , filtered, the clathrate was dried at low temperature, and pulverized for later use. Evodia rutaecarpa and coptis 1284g, reflux extraction with 60% ethanol for 3 times, each time for 1h, combine the extracts, recover ethanol under reduced pressure; Macroporous resin column (amount of 1500g, conventional pretreatment, the ratio of medicinal material to resin amount is 1:1), the adsorption flow rate is 1BV / h, the impurities are eluted with distilled water, the elution flow rate is 2BV / h, and bismuth potassium iodide test solution is used Determine the end point of water washing, and finally elute the active ingredient with 60% ethan...

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Abstract

The invention discloses a Zuojinwei floating capsule and a preparation method thereof. The capsule is made by mixing Zuojin extract and gastric flotation auxiliary materials at a weight ratio of 1:0.5-5, Zuojin extract is prepared by extracting Coptidis Rhizoma and Evodia rutaecarpa at a weight ratio of 6:1, and gastric flotation auxiliary materials include hydrophilic gel materials, auxiliary flotation materials, blowing agents and release modifiers. Preparation method: take the volatile oil extracted from Evodia rutaecarpa and clathrate it with β-cyclodextrin, combine the dregs of Evodia rutaecarpa and Coptis chinensis, extract with ethanol, mix the extract and auxiliary materials in proportion, pack into capsules, and heat and solidify. The capsule is used for treating gastric diseases such as acute and chronic gastritis and peptic ulcer. Compared with Zuojin pill, the capsule stays in the stomach for a long time, which can prolong the clinical curative effect.

Description

1. Technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a Zuojinwei floating capsule and a preparation method thereof. 2. Background technology [0002] Zuojin Wei Floating Capsule is an improvement of the dosage form of Zuojin Pill or Zuojin Capsule, which are already on the market. Zuojin Wan comes from "Danxi Xinfa". It is composed of the monarch drug Coptis chinensis and the adjuvant drug Evodia rutaecarpa in a ratio of 6:1. It is recorded in various editions of the Chinese Pharmacopoeia. Pain in the stomach and hypochondriac, bitter and noisy mouth, vomiting of sour water, dislike of hot drinks. At present, it is commonly used clinically for acute and chronic gastritis and peptic ulcer, and the curative effect is remarkable. Modern pharmacological studies have shown that Zuojin Wan has the functions of anti-ulcer, protecting gastric mucosa, inhibiting gastric acid secretion, and affecting gastrointest...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/754A61K9/48A61P1/04
Inventor 刘陶世段金廒狄留庆赵新慧蔡宝昌黄耀洲
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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