Gastric floating capsule of 'Zuo Jin Wan' and preparation method thereof
A gastric flotation and capsule technology is applied in the field of Zuojin gastric flotation capsule and its preparation, and achieves the effects of clear ingredients, high technical content and clear mechanism of action
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Embodiment 1
[0052] (1) Raw material prescription: Coptidis 1284g, Evodia 214g.
[0053] (2) Extraction and refinement: take 214g of Evodia rutaecarpa medicinal material, extract the volatile oil by steam distillation for 3.0 hours; weigh β-cyclodextrin (g / ml) equivalent to 8 times the amount of volatile oil, and adopt the saturated aqueous solution method to clathrate at 60°C for 3 hours, Refrigerate, filter, dry the clathrate at low temperature, and pulverize for later use. Evodia rutaecarpa and coptis 1284g, reflux extraction with 60% ethanol for 3 times, 1 hour each time, combine extracts, recover ethanol under reduced pressure; Sodium oxide aqueous solution to neutralize sulfuric acid, add 95% medicinal ethanol to make the alcohol concentration of the medicinal solution 80%, let it stand, and filter; the filtrate recovers ethanol, vacuum-dries, pulverizes through a 100-mesh sieve, and clathrates with β-cyclodextrin of volatile oil The mixture was evenly mixed to obtain 200 g of Zuoji...
Embodiment 2
[0056] (1) Raw material prescription: Coptidis 12.84kg, Evodia 2.14kg.
[0057] (2) Preparation: Take 12.84 kg of Coptis chinensis and 2.14 kg of Evodia rutaecarpa, grind them into coarse powder, extract by percolation with 0.5% sulfuric acid aqueous solution, collect about 150 L of percolation liquid, neutralize it with 40% sodium hydroxide solution, and depressurize Concentrate to 15kg, add 95% ethanol until the ethanol concentration of the liquid medicine system is 80%, let it stand for more than 6 hours, and filter; the filtrate recovers ethanol under reduced pressure, vacuum-dries, pulverizes and passes through a 100-mesh sieve to obtain 1850 g of Zuojin extract .
[0058] (3) Preparation molding: Weigh 800g of hydroxyethyl cellulose, 200g of sodium carboxymethyl cellulose, 500g of stearic acid, 200g of stearyl alcohol, 100g of sodium bicarbonate, 350g of polyethylene glycol (PEG 6000) and Zuojin 1850g of the extract was mixed evenly, filled in hard capsules (0.4g / capsul...
Embodiment 3
[0060] (1) Ingredients: Coptidis 1284g, Evodia 214g.
[0061] (2) Preparation: take 214g of Evodia rutaecarpa medicinal material, extract the volatile oil by steam distillation for 3.0h; weigh β-cyclodextrin (g / ml) equivalent to 8 times the amount of volatile oil, adopt saturated aqueous solution method for inclusion at 60°C for 3h, and refrigerate , filtered, the clathrate was dried at low temperature, and pulverized for later use. Evodia rutaecarpa and coptis 1284g, reflux extraction with 60% ethanol for 3 times, each time for 1h, combine the extracts, recover ethanol under reduced pressure; Macroporous resin column (amount of 1500g, conventional pretreatment, the ratio of medicinal material to resin amount is 1:1), the adsorption flow rate is 1BV / h, the impurities are eluted with distilled water, the elution flow rate is 2BV / h, and bismuth potassium iodide test solution is used Determine the end point of water washing, and finally elute the active ingredient with 60% ethan...
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