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Biological degradation polymer based on alpha-L-proline

A biodegradation and proline technology, applied in the field of high-performance biodegradable polymer materials, can solve problems such as poor strength and environmental pollution, and achieve good biocompatibility.

Inactive Publication Date: 2010-01-20
张为鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the hot melt adhesives currently on the market are non-degradable polymers, causing more and more serious pollution to the environment
However, the biodegradable hot melt adhesives of natural polymers have poor strength.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 23 grams of α-L-proline, 235.8 grams of 6-aminocaproic acid, mix well (molar ratio 10:90), under nitrogen protection, place in a 500 ml flask, heat at 250°C for 1 hour, then place in Heat at 250°C for 3 hours under a vacuum of 13 Pa. After the reaction was stopped, the melting point of the synthesized material was 200° C., the tensile strength was 42.9 MPa, the elongation at break was 63%, and the enzymolysis weight loss rate in 4 weeks was 2.4%.

Embodiment 2

[0019] Weigh 46 grams of α-L-proline and 78.6 grams of 6-aminocaproic acid, mix well (molar ratio 40:60), place in a 250 ml flask, and react in a microwave oven at 800W for 0.5 hours. After the reaction was stopped, the synthesized material was in an amorphous state, with a tensile strength of 7.8 MPa, an elongation at break of 20%, and a weight loss rate of 15.1% after 4 weeks of enzymatic hydrolysis.

Embodiment 3

[0021] Weigh 69 grams of α-L-proline, 203 grams of 6-aminocaproic acid, mix well (molar ratio 30:70), under nitrogen protection, place in a 500 ml flask, heat at 230°C for 2 hours, and then Heat at 250°C for 2 hours under a vacuum of 13 Pa. Stop the reaction, the synthesized material is in an amorphous state, the tensile strength is 13.0 MPa, the elongation at break is 48.5%, and the enzymolysis weight loss rate is 10.2% in 4 weeks.

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PUM

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Abstract

The invention relates to a biodegradation polymer with good allround properties on the basis of alpha-L-proline. The material uses the alpha-L-proline and one or a plurality of omega-amino acids, or the lactam of the omega-amino acid as raw materials, and does or does not contain other raw materials; wherein, the mole ratio of the alpha-L-proline in the raw materials is 8 to 60 percent. The material has better mechanical property, and the material, the raw materials and a degradation product have small toxicity and can have biodegradation. The material is not only expected to be used as a biology medical material, like the bracket material of a tissue project, the releasing material of medicine or gene, suture, artificial skin, etc., but also can be used as packing material of food and other things, moreover, can be used as biodegradation hot-melt adhesive.

Description

field of invention [0001] The invention relates to a class of high-performance biodegradable polymer materials. This type of new material has good mechanical properties (both high strength and good flexibility), and the raw materials and degradation products are amino acids that make up organisms and ω-amino acids with little toxicity. The material is not only expected to be used as biomedical materials, such as tissue engineering scaffold materials, slow-release and controlled-release materials for drugs or genes, sutures, artificial skin, etc., but also can be used as packaging materials for food and other items, and can be used as biodegradable hot melt materials. glue used. Background technique [0002] Tissue engineering scaffold material is one of the key technologies of tissue engineering. Scaffold materials provide a three-dimensional space for cell growth, differentiation and reproduction. However, the currently used biodegradable polymer scaffold materials have ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G69/08
Inventor 张为鹏
Owner 张为鹏