Ossotide glucose injection

A glucose injection and glucose technology, applied in the field of osteopeptide glucose injection and its preparation, can solve the problems of secondary pollution of drugs, generation of pyrogenic reactions, and impact on drug safety, so as to facilitate clinical use and promote new bone formation , the effect of reducing adverse reactions

Inactive Publication Date: 2007-07-18
陈卓涛 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since peptide injections are usually infused intravenously in clinical use, they need to be temporarily dissolved in 200ml of 0.9% sodium chlorid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Osteopeptide Glucose Injection, take healthy fresh pig limb bones, add pure water at 1.2 kg / cm 2 Hot-press extraction for 1.5h, filter, add pure water to the bone residue and hot-press for 1h, filter, combine the filtrates twice, stand in a cold room at 0-5°C for 12h, remove the upper layer of fat, and concentrate in vacuum below 70°C to 1 / 5 of the volume of the filtrate Add 95% ethanol until the final concentration is 70% (v / v), precipitate and filter out impurities to obtain a clear solution, concentrate in vacuum below 60°C to about 1 / 4, add pure water to 1 / 2 of the total Volume, dilute the ethanol-free concentrated solution with water to the total volume, adjust the pH to 4.0±0.1 with HCL, filter with activated carbon at 100°C to obtain the filtrate, adjust the pH with NaOH to 7.0-7.2, filter with activated carbon at 80°C, cool, and molecular weight cut-off 10000 ultrafiltration column superfluid, cooled to obtain bone peptide raw material liquid; weigh 5 kg of gluc...

Embodiment 2

[0009] Take healthy fresh pork limb bones, add pure water to 1.2 kg / cm 2 Hot-press extraction for 1.5h, filter, add pure water to the bone residue and hot-press for 1h, filter, combine the filtrates twice, stand in a cold room at 0-5°C for 12h, remove the upper layer of fat, and concentrate in vacuum below 70°C to 1 / 5 of the volume of the filtrate Add 95% ethanol until the final concentration is 70% (v / v), precipitate and filter out impurities to obtain a clear solution, concentrate in vacuum below 60°C to about 1 / 4, add pure water to 1 / 2 of the total Volume, dilute the ethanol-free concentrated solution with water to the total volume, adjust the pH to 4.0±0.1 with HCL, filter with activated carbon at 100°C to obtain the filtrate, adjust the pH with NaOH to 7.0-7.2, filter with activated carbon at 80°C, cool, and molecular weight cut-off 10000 ultrafiltration column ultrafiltration, cooling to obtain bone peptide raw material solution; weigh 5 kg of glucose, add water for inje...

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PUM

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Abstract

An injection for promoting the healing of bone fracture is prepared from bone peptide extracted from the limb bone of pig, glucoside and the water for injection through proportionally adding glucose to the raw liquid of bone peptide, and diluting with the water for injection.

Description

technical field [0001] The invention relates to an osteopeptide glucose injection and a preparation process thereof. Background technique [0002] The main component of osseopeptide is a small molecule polypeptide substance, which is a mixture of small peptides decomposed from collagen. During storage, it can self-polymerize to form larger molecules. With the prolongation of storage time, the precipitation of polymers increases, thereby producing antigens. Its polymerization increases with the increase of the concentration of peptides, which causes an increase in the incidence of allergic reactions in clinical applications, up to 0.1%. Generally, rashes, fever, and hypotension begin to appear after 5-6 days of medication. Since peptide injections are usually infused intravenously in clinical use, they need to be temporarily dissolved in 200ml of 0.9% sodium chloride injection, which will easily cause secondary pollution of drugs and pyrogenic reactions during static injectio...

Claims

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Application Information

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IPC IPC(8): A61K38/02A61K9/02A61K47/26A61P19/08
Inventor 陈卓涛
Owner 陈卓涛
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