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Use of GADD45 beta protein and its inhibitor in treatment of rheumatoid arthritis

A β protein and inhibitor technology, applied in the application field of GADD45 β protein and its inhibitors in rheumatoid arthritis, can solve the problems of unclear, hindering the diagnosis and treatment of rheumatoid arthritis, and unexplained functional relationship.

Inactive Publication Date: 2007-08-08
SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The relationship between the expression of GADD45β protein and rheumatoid arthritis has not been reported so far
In particular, prior to the present invention, the overexpression of GADD45β protein in RA synovial infiltrating T cells and T cells in peripheral blood and its functional relationship in RA had not been elucidated
[0007] Since the pathogenesis of rheumatoid arthritis, especially the molecular mechanism of initiation and persistence of rheumatoid pathogenic CD4+ T cells, remains unclear, thus greatly hindering the diagnosis and treatment of rheumatoid arthritis

Method used

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  • Use of GADD45 beta protein and its inhibitor in treatment of rheumatoid arthritis
  • Use of GADD45 beta protein and its inhibitor in treatment of rheumatoid arthritis
  • Use of GADD45 beta protein and its inhibitor in treatment of rheumatoid arthritis

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Embodiment Construction

[0054] The present invention clarifies the mechanism of action of GADD45β protein in RA inflammatory process and other autoimmune conditions. Studies have shown that the expression of GADD45β protein in peripheral blood mononuclear cells and CD4+ T cells of rheumatoid arthritis is significantly increased, and the expression of GADD45β protein in peripheral blood mononuclear cells and CD4+ T cells of normal people can be induced by synovial fluid of inflammatory joints . Increased expression of GADD45β protein provides a functional mechanism for amplifying inflammation during the continuous activation of pathogenic T cells in rheumatoid patients. The present invention has been accomplished on this basis.

[0055] In the present invention, the high expression of GADD45β protein in the diseased synovial tissue and cells was found for the first time, and the method of stimulating the diseased synovial fluid in vitro showed that the overexpression of peripheral blood T cells has a...

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Abstract

The invention relates to a GADD45beta protein and relative restrainer, in the application of atrophic arthritis treatment. Said agent comprises GADD45beta protein and cell factor, one or combination of descending kinases of GADD45beta protein, wherein, said cell factor comprises IFN-gamma and TNF-alpha for improving the expression of GADD45beta and the effective inducing agent IL-12 and IL-18 for improving the expression of GADD45beta. And the inventive drug compound comprises the restrainer with safe amount of GADD45beta protein which comprises GADD45beta protein antibody, reverse sequence of GADD45beta protein code sequence, natural vegetable extractive or chemical agent and IL-12 / 18 antibody, GADD45beta nucleic acid specific small molecule RNA, acceptable carrier of shaping agent, while said safe amount is that one to five 1micrograms of restrainer can be used in one kilogram weight.

Description

technical field [0001] The application of the GADD45β protein and its inhibitor in rheumatoid arthritis of the present invention relates to the technical fields of biological detection, diagnosis and new drugs, specifically, the present invention relates to a protein that plays an important role in the pathogenesis of rheumatoid arthritis -Use of GADD45β protein and its inhibitor in the treatment of rheumatoid arthritis. The invention also provides a corresponding drug screening method, which is also applicable to other autoimmune diseases and other tumor treatment and drug screening methods with high expression of GADD45β. Background technique [0002] Although the etiology and pathogenesis of rheumatoid arthritis (RA) are still unclear, it has been recognized that T cell-mediated inflammation plays an important role in the process of rheumatoid synovial lesions. Type II collagen and heat shock protein are autoantigens in the pathogenesis of rheumatoid arthritis, although ...

Claims

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Application Information

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IPC IPC(8): A61K38/19A61K38/55A61K39/395A61K9/08A61K9/20A61K9/48A61P29/00A61P19/02A61P35/00A61P37/02
Inventor 李宁丽王利阿东仪沈佰华
Owner SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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