Supersonic microvesicle target positioning controlled-release/gene device and target transferring method

An ultrasonic microbubble and controlled-release drug technology, applied in the field of biomedical engineering, can solve problems such as invasiveness, lack of drug/gene-specific devices, low transfection rate, etc., and achieve the effect of improving transmission efficiency

Active Publication Date: 2007-09-05
RONGHAI SUPERSONIC MEDICINE EN
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0003]In the gene transfer technology, although the existing virus carrier has a high gene transfection rate, there are problems such as safety and the body's immune response to the virus; and other non-viral vectors, although safe, but the transfection rate is low
Proteins, peptides, and chemotherapeutic drugs, like gene drugs, have the disadvantages of poor targeting by intravenous injection, and the amount of drugs/genes reaching specific tissues is small and inefficient; local injection of drugs/genes has a limited scope of application and Invasive and other issues
At present, there are many unresolved problems in the field of drug/gene delivery technology, especially the lack of safe, effective

Method used

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  • Supersonic microvesicle target positioning controlled-release/gene device and target transferring method
  • Supersonic microvesicle target positioning controlled-release/gene device and target transferring method
  • Supersonic microvesicle target positioning controlled-release/gene device and target transferring method

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Embodiment Construction

[0026] The content of the present invention will be described in further detail below in conjunction with the embodiments and the accompanying drawings.

[0027] The following examples are non-limiting examples of the invention.

[0028] As shown in Figure 1, the ultrasonic microbubble targeted positioning and controlled release drug / gene device of the present invention includes an ultrasonic monitoring unit 2, an ultrasonic triggering / treatment unit 3, a drive unit 5 for driving the ultrasonic triggering / treatment unit 2 to emit ultrasonic waves, and a computer control unit. The unit 4 and the cooling unit 6, wherein the computer control unit 4 is connected to the ultrasonic monitoring unit 2 and the ultrasonic triggering / treatment unit 3 respectively, and the driving unit 5 and the cooling unit 6 are connected to the ultrasonic triggering / therapy unit 3 respectively. The ultrasonic triggering / treatment unit 3 is used to trigger the destruction of microbubbles to achieve drug...

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Abstract

An ultrasonic microvesicle apparatus for directional location and release control of medicine or gene is composed of an ultrasonic triggering-therapeutic unit, a driver unit, an ultrasonic monitor unit, and a computer control unit consisting of host, display, image acquisition card, etc. A method for combining the microvesicle contrast medium with medicine or gene and using ultrasonic wave for target transfer is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and in particular relates to an ultrasonic microbubble targeted positioning and controlled release drug / gene and effect evaluation device and a method for combining microbubble contrast agent and drug / gene with ultrasound to realize targeted transfer. Background technique [0002] Drug / gene delivery is a key technology to fully exert the biological effects of the drug / gene itself. At present, the common drug / gene delivery carriers are viral and non-viral, such as direct drug / gene injection, liposome-mediated, receptor-mediated, particle bombardment technology, electroporation, etc. [0003] Although the existing viral vectors in gene transfer technology have a high gene transfection rate, there are problems such as safety and the body's immune response to the virus; non-viral vectors such as plasmids are safe, but the transfection rate is low. Proteins, peptides, and chemotherapeu...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/22A61K48/00A61K47/00
Inventor 王志刚冉海涛许川山张群霞凌智瑜郑元义燕思源
Owner RONGHAI SUPERSONIC MEDICINE EN
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