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Breeding method of making small mouse have the pathological feature of spontaneity dizzy feeling

A cultivation method and spontaneous technology, applied in the field of medical experimental animal models, can solve the problems of lack of animal models of motion sickness and no major breakthroughs in research work.

Inactive Publication Date: 2007-09-26
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the lack of satisfactory animal models of motion sickness, there has been no major breakthrough in research work in this area

Method used

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  • Breeding method of making small mouse have the pathological feature of spontaneity dizzy feeling
  • Breeding method of making small mouse have the pathological feature of spontaneity dizzy feeling
  • Breeding method of making small mouse have the pathological feature of spontaneity dizzy feeling

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0013] 260 Kunming adult mice, half male and half male. According to the dizziness response index of the mice as shown in Figure 1 and Figure 2, screen them, put the animals in the WTD500A controllable three-arm rotator hanger, and rotate them forward at 60 times / min for 40 minutes to stun , after the spin is over, place the animal on the ground and observe the animal's reaction immediately. After scoring according to the scoring standard in Table 1, calculate the response index (the sum of the scores in the table).

[0014] indicators

scoring

Defecation

to urinate

standing hair

trembling

No, 0 points; Yes, 1 point per grain

No, 0 points; Yes, 1.2 points

None, 0 points: mild, 0.6 points: severe 1.2 points

No, 0 points; Yes, 1.2 points

[0015] Select 8 pairs of mice with the highest halo reaction index as the F1 progeny to cultivate the next generation. The progeny are screened in the same way, and the offspring are...

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Abstract

The invention discloses a cultivate method for making mouse with spontaneous faint sensitive pathological character, comprising the tested animals and operation method. The invention is characterized in that the invention uses KunMing mouse as resource and the operation method comprises that the mature mouse have equal male and female numbers, to be selected according to the faint index to select 8 couples with maximum faint index as F1 sub generation to cultivate next generation, and selects the sub generation via same method, and uses consanguinity copulation method to cultivate sub generation or the like, while the invention selects 8 couples of minimum faint index as reference, repeats the selection and cultivates more than 12 generations, to obtain the mouse with spontaneous faint sensitive pathological character and stable gene character and normal ones. The inventive mouse can be used to research motion sickness or the like.

Description

Technical field: [0001] The invention relates to the technical field of medical experimental animal models, in particular to a breeding method for making mice with pathological characteristics of spontaneous dizziness sensitivity, so that the mice with the pathological characteristics of spontaneous dizziness sensitivity can be used for screening motion sickness drugs. Background technique [0002] Motion sickness refers to a disease caused by general discomfort caused by riding various means of transportation. The main symptoms are dizziness, nausea, vomiting, and cold sweats. With the development of society and the process of global integration, people need to travel more and more frequently by means of transportation. In addition to bringing unprecedented convenience to people's lives, fast transportation has also led to a rapid increase in the incidence of motion sickness. Due to the lack of satisfactory animal models of motion sickness, there has been no major breakth...

Claims

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Application Information

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IPC IPC(8): A01K67/02
Inventor 苏定冯于旭红韩娉刘爱军楚正绪
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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