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Device for photodetecting tumor

A photoelectric detection, tumor technology, applied in the direction of measuring device, color/spectral characteristic measurement, application, etc., can solve the safety problems of normal cells and tissues, etc.

Inactive Publication Date: 2007-10-03
KK TOSHIBA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since radioactive substances are injected into the living body, this physiological diagnostic method is necessarily accompanied by safety issues of normal cells and tissues

Method used

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  • Device for photodetecting tumor
  • Device for photodetecting tumor
  • Device for photodetecting tumor

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0049] Two types of hemoglobin (oxidized and normal) and glucose were chosen as absorbers to be measured. In place of biological tissue, prepare the following model specimen. That is, first, a silicone resin is selected as a base material. Then, a scattering material (10% lipid particle scattering liquid, product name: Intralipid) and an absorbing material (near-infrared region dye, product name: GreenishGreen) were dispersed in silicone resin, and the resultant was cured, thereby preparing a simulation Lipid. The simulated lipids exhibited the same optical constants (scattering and absorption coefficients) as natural lipids. The simulated lipids were cut into pieces with different thicknesses from 5 mm to 30 mm (in steps of 5 mm), and thus thin plates of simulated lipids were fabricated. Subsequently, a silicone resin was selected as the above-mentioned base material, and a cube capable of accommodating the test specimen was fabricated. In the surface portion of the cube,...

example 2

[0058] The device was evaluated using the same model specimen as in Example 1.

[0059] The wavelengths to be measured were set to 760 nm, 840 nm, and 1640 nm to match the absorption bands of hemoglobin, oxyhemoglobin, and glucose, respectively. Three near-infrared LDs (pulsed oscillating LDs with a time interval of 10 ns and a repetition frequency of 10 kHz) were selected as light sources. The modulated light beam output by the LD is synthesized on the optical filter, and the synthesized light is irradiated on the specimen through a single optical fiber (quartz single-core type, 250 μm in diameter). Meanwhile, the acoustic element is tightly attached to the surface perpendicular to the light incident surface via the acoustic matching layer, performing the detection of the acoustic wave. The acoustic signal is fed to a lock-in amplifier where the signal of the LD driver is applied as an external trigger, so the output of the LD can be detected independently. Use the main amp...

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Abstract

The present invention includes i) an irradiator which irradiates 1st light with wavelength within a photo-absorption band of glucose on organism tissues, ii) an detector which detects reflected light of the 1st light from the organism tissues, iii) an operation unit configured to operate distribution of level of glucose, and iv) a determination unit configured to determine presence of a tumor by analyzing the distribution of level of glucose.

Description

technical field [0001] The invention relates to a tumor photoelectric detection device capable of non-invasive inspection inside a living body. Background technique [0002] Early detection of tumors is very important for the treatment of tumors, and thus, in order to detect tumors at an early stage, various methods and techniques are utilized. [0003] First, a conventionally known method is a topological diagnostic method (for example, as described in JP-A 2005-328507 (KOKAI)). This topological diagnosis method is a diagnosis method for detecting a tumor position based on a value obtained by measuring a physical constant (X-ray absorption coefficient or acoustic impedance). More specifically, the X-ray absorption coefficient and / or the acoustic impedance of biological tissue are measured at a plurality of positions, and a region in a living body that is different from a normal position is detected based on a difference in the measured values. Then, the distribution statu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00G01N21/31A61B10/00G01N21/00G01N21/35G01N21/3554G01N21/359
CPCA61B5/0091A61B5/1455A61B5/0086A61B5/0095A61B5/14532A61B5/4312
Inventor 浦野妙子
Owner KK TOSHIBA