External applied spraying agent with tioconazole and its preparation method

A technology of tioconazole and spray, which is applied in the field of topical spray containing tioconazole and its preparation, can solve the problems of high cost, slow speed, uneven drug distribution, etc., and achieve the effect of easy implementation and cost reduction

Inactive Publication Date: 2007-10-24
SHANGHAI GOLDEN PHARMATECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of topical spray that contains tioconazole, and described this topical spray that contains tioconazole will solve when tioconazole is used in the form of ointment in the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Dissolve 1g of tioconazole in 60ml of absolute ethanol, then add distilled water to 100ml, and finally divide into 10ml brown glass bottles.

Embodiment 2

[0021] Dissolve 2g of tioconazole in 70ml of absolute ethanol, then add distilled water to 100ml, and finally divide into 15ml opaque plastic bottles.

Embodiment 3

[0023] Dissolve 1g of tioconazole in 50ml of absolute ethanol, then add distilled water to 100ml, and finally divide into 10ml opaque plastic bottles.

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PUM

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Abstract

The invention relates to a tioconazole -containing exterior spraying agent, comprising tioconazole and medical findings. The weight of tioconazole is 0. 1-10% of the total weight of exterior spraying agent, and the left is medical findings. The tioconazole dissolves in the findings. The invention also discloses a method for preparing said product, which includes one step of dissolving tioconazole in the solvent. The step comprises: dissolving tioconazole in absolute ethyl alcohol and diluting tioconazole and absolute ethyl alcohol with distilled water. The invention mixed tioconazole with solvent, and forms formulation suitable for spraying agent. It overcomes problems of slow volatilization, long residual time, uneven medical distribution, slow speed of medicine reaching to injured place of paste agent, it can be used to treat tinea corporis, scald and ringworm of the nails and other body fungus infection.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an external spray containing tioconazole and a preparation method thereof. Background technique [0002] Tioconazole is a new generation of imidazole antifungal drugs with strong efficacy and broad antibacterial spectrum. Its biggest feature is that it is difficult to enter the blood circulation through the skin and mucous membranes. Therefore, it has almost no systemic effect when used as a local drug, thus avoiding some toxic and side effects. [0003] Tioconazole was first developed by Pfizer, and filed a patent application for this product compound in the United States in 1975, with the patent number US4062966. Pfizer's topical tioconazole product was approved as an OTC product (NDA18,682) in 1983 and has been marketed in more than 30 countries around the world. But tioconazole spray has not been produced and sold globally. [0004] Pfizer applied for the patent of the tioconazole co...

Claims

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Application Information

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IPC IPC(8): A61K31/4174A61K47/10A61K9/12A61P31/10
Inventor 张剑亮
Owner SHANGHAI GOLDEN PHARMATECH
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