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Pulse engendendering active component composition and its preparation

A technology of Shengmai and powder injections, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and non-active ingredients of polymer compounds, etc., to achieve multi-benefit, significant curative effect, and quality-controllable effects

Inactive Publication Date: 2014-12-10
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing Shengmai preparations have imperfect extraction processes, incomplete extraction of active ingredients, difficult product quality control, and low and imperfect preparation quality standards. For example, Shengmai injections use Tween co-solvents that are not allowed to be added to cardiovascular drugs. , the drug concentration is low, the clinical dosage is large, and the transportation and storage are also inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Preparation of Radix Ginseng Mixed Saponins Extract

[0022] method 1:

[0023] Weigh ginseng leaves and Ophiopogon japonicus medicinal materials in the ratio of 1:0.9 parts by weight, add water and boil to extract three times and control the pH, the first time is 6 times of the amount of medicinal materials and 0.7% Na2CO3 The second time is the amount of medicinal materials 4 times the amount of water and 0.3% Na2CO3 of the amount of medicinal materials, the third time is 4 times the amount of water of the medicinal materials; side countercurrent circulation extraction, after boiling, keep for 1.5, 1, and 1 hour respectively; the medicinal liquids are combined and cooled to room temperature, filtered, and the medicinal liquid filtrate Put on the treated macroporous weakly basic anion D392 exchange column (Nankai University Chemical Plant), rinse with 2% NaOH solution of 2 times the volume of the resin bed, and discard the rinse solution; then rinse with pur...

Embodiment 2

[0034] The preparation of embodiment two ginseng radix mixed saponins extract

[0035] method 1:

[0036] Take by weighing red ginseng and Ophiopogon japonicus medicinal materials in the ratio of 1: 6.9 parts by weight, add 50% ethanol to reflux and extract three times and control the pH, the first time is Na2CO3 of 5 times the amount of 50% ethanol and 1% of the amount of medicinal materials, the second The second time is 4 times the amount of 50% ethanol and 0.5% Na2CO3 of the amount of medicinal materials, and the third time is 4 times the amount of 50% ethanol of the amount of medicinal materials; side countercurrent circulation reflux extraction, keep 1.5, 1, 1 respectively after the reflux begins hours; filter the medicinal liquid and combine the filtrates, concentrate the filtrate under reduced pressure at 70°C until there is no alcohol smell, then dilute the concentrated liquid with water until the ratio of the medicinal material to the liquid is 1:1.5, and the macrop...

Embodiment 8

[0041] The preparation of embodiment three Schisandra chinensis total lignans

[0042] method 1:

[0043] Take the schisandra medicinal material, add 50% ethanol to reflux and extract three times and control the pH, the first time is 5 times the amount of medicinal material 50% ethanol and 1% Na2CO3, the second time is 4 times the amount of medicinal material 50% ethanol and 0.5% The amount of Na2CO3 is the amount of medicinal material, and the third time is 50% ethanol with 4 times the amount of medicinal material; the side countercurrent circulation is extracted, and the reflux is kept for 1.5, 1, and 1 hour respectively; After the alcohol smell is gone, the concentrated solution is diluted with water until the ratio of medicinal materials to liquid is 1:1.5, the treated macroporous adsorption resin column D101 on the diluted solution is rinsed with 0.4% NaOH twice the volume of the resin bed, and the rinse solution is discarded; Rinse with 2 times of pure water again, and...

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PUM

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Abstract

The invention belongs to medical preparation field, specifically discloses a sheng mai effective fraction composition and its preparation. The sheng mai effective fraction composition comprises mixed saponins extract of Panax ginseng and Ophiopogon japonicus and total lignanoid of Schisandra Chinesis. Inventive sheng mai effective fraction composition can be made into different kinds of dosage forms with any adjuvants such as injection, tablet, sustained release tablet, dripping pill, granule, powder injection, capsule and fine granule. The invention Chinese medicinal composition has easily accessible resource, easy industrialization; can be made into different kinds of dosage forms, provides Chinese traditional medicine with conveniece, efficiency and controlled quality, and bring benefit for patient; thereby generating giant social benefit.

Description

technical field [0001] The invention belongs to pharmaceutical preparations, in particular, it relates to the composition of active parts of Shengmai and its preparation. Background technique [0002] At present, the existing Shengmai preparations are all made of red ginseng, Ophiopogon japonicus and Schisandra chinensis as raw materials. This prescription originated from Shengmai Yin in Jin Dynasty Li Gao's "Internal and Internal Injury Discrimination and Confusion". It is widely used clinically for deficiency of both qi and yin. It has a good curative effect on the stable stage of coronary heart disease patients, acute myocardial infarction, cardiogenic shock, arrhythmia and other acute stages, septic shock and other critical illnesses. It can also be used as an adjuvant drug for cancer treatment, and can be used to alleviate adverse reactions caused by chemotherapy and radiotherapy. However, the existing Shengmai preparations have imperfect extraction processes, incompl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K36/8968A61K47/40A61P9/10A61P9/06A61P9/02
Inventor 杨悦武叶正良郑永锋李旭
Owner TIANJIN TASLY ZHIJIAO PHARMA