Modified HPV E6-E7 fusion gene and coding protein thereof

A HPV16E6-E7, fusion gene technology, applied in the field of fusion genes and their encoded proteins
CN101100672AInactive Publication Date: 2008-01-09曾毅
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
曾毅
Publication Date
2008-01-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

A code optimizing HPV16 E6-E7 fused gene, fused gene with carcinogenicity elimination by fixed-point mutagen and it encoded fused protein are disclosed. The modified fused genes are increased in mammal cell expression. It has excellent cell conversion activity and biological safety. It can be used to offer excellent provisional antigen gene for constructing related DNA vaccine.
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Description

technical field

[0001] The invention belongs to the fields of genetic engineering and tumor treatment. Specifically, the present invention relates to a codon-optimized HPV16E6E7 fusion gene and its encoded protein, as well as three potential carcinogenicity-eliminated fusion genes obtained by site-directed mutagenesis of the codon-optimized HPV16 E6E7 fusion gene and its encoded protein. coded protein. Background technique

[0002] Human papillomavirus (Human Papillomavires, HPV) is a kind of DNA virus with strict host range and tissue specificity. It mainly infects human skin or mucosal epithelial cells, causing benign and malignant lesions at the infection site. With the deepening of HPV research, it is found that about 80% of cervical cancers are related to four types of HPV infection, namely HPV16, 18, 31 and 45, and 50% of cervical cancers are related to HPV16 infection (MH Stoler . Int J Gynecol Patho, 2000, 19(1): 16-28). According to statistics, there are about 51...

Claims

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