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Artificial calculus bovis medicinal composition without smell of mutton, stench and bitter and preparation thereof

A technology of artificial bezoar and composition, which is applied in the directions of drug combination, non-active ingredients of polymer compounds, medical preparations containing active ingredients, etc. stable effect

Inactive Publication Date: 2008-03-26
李杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to overcome the specific mutton, stench and bitter taste of artificial bezoar, overcome the problems of poor taste of artificial bezoar tablets on the market, not suitable for oral application of patients, especially children and infants, etc., by adopting special drug combination and common preparation technology, prepared a kind of artificial bezoar pharmaceutical composition without smell, fishy smell and bitter taste, the preparation of this pharmaceutical composition is dry suspension, granule, tablet and dispersible tablet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1. Artificial bezoar pharmaceutical composition one:

[0019] Weigh artificial bezoar 100, xanthan gum 7, β-hydroxypropyl cyclodextrin 520, aspartame 15, sucrose 340, fresh creamer 8, lemon flavor 10 parts, and dry other raw materials except spices in advance To the moisture content below 1%, crush into fine powder of 80-100 mesh or more, and then mix uniformly according to the step-by-step dilution method to obtain.

Embodiment 2

[0020] Example 2. Artificial bezoar pharmaceutical composition two:

[0021] Weigh 20 parts of artificial bezoar 200, xanthan gum 20, β-cyclodextrin 780, stevioside 20, lactose 300, sucrose 655, fresh cream 5, banana flavor, and dry the other raw materials except flavors to moisture in advance 1% or less, pulverize into fine powder of 80-100 mesh or more, and then mix uniformly according to the step-by-step dilution method to obtain.

[0022] By changing the drug combination of Example 1 and Example 2, and adding the above-mentioned taste masking agent, sweetening agent and aroma correcting agent, different pharmaceutical compositions can be prepared. Using the above-mentioned pharmaceutical composition, according to the usual preparation process, according to the requirements of different dosage forms, adding different excipients, artificial bezoar dry suspensions, granules, tablets and dispersible tablets can be prepared respectively, and various artificial bezoars can be prepar...

Embodiment 3

[0023] Example 3. Artificial bezoar dry suspension:

[0024] On the basis of the artificial bezoar pharmaceutical composition prepared in Example 1 and Example 2, an appropriate amount of thickening agent and suspending agent such as one or more of hydroxypropyl cellulose, hypromellose, carboxymethyl are added. Sodium cellulose, gum arabic, gelatin, carbomer, alginate are mixed uniformly according to the stepwise dilution method, and then they can be packaged. The amount per bag is 1 to 3g.

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PUM

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Abstract

The present invention relates to a medicinal artificial cow-bezoare medicine composition and its preparation. Said medicine composition contains (by wt%) 2-35% of artificial cow-bezoare, 30-75% of taste masking agent, 10-60% of sweetening agent and 0.5-5% of correctives. Said medicine composition can be made into suspension preparation granules preparation, tablet preparation and dispersion tablet preparation.

Description

Technical field [0001] The invention relates to an artificial bezoar pharmaceutical composition without mutton, fishy smell and bitter taste for medicine and its preparation. Background technique [0002] Bezoar is a kind of precious medicinal material. Because natural bezoar resources are scarce, expensive, and long-term dependence on imports, my country has developed artificial bezoar as a substitute for natural bezoar as early as the 1950s. Artificial bezoar has been included in the 2005 edition of the Chinese Pharmacopoeia. Pharmacological studies have proved that the pharmacological effects of artificial bezoar are similar to those of natural bezoar. It has the effects of clearing heat, detoxifying, resolving phlegm, and calming convulsions. It is clinically used for phlegm fever, delirium, faintness, fever and convulsion in children, sore throat, mouth and tongue Sores, carbuncle, swollen boils, etc. Reported clinical data indicate that artificial bezoar is effective in tre...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/20A61K9/16A61K47/40A61P11/00
Inventor 李杰
Owner 李杰
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