The invention discloses a method for preparing dapoxetine
hydrochloride. The method comprises the following steps: subjecting (s)-3-amino-3-phenylpropionic acid or an ester thereof to a reduction reaction in a reduction
system prepared from a hydroborate and a
boron trifluoride complex, so as to obtain an intermediate 1, i.e. (s)-3-amino-3-phenylpropanol; subjecting the (s) intermediate 1 to an Eschweiler-Clark reaction with
formic acid and
formaldehyde, so as to obtain an intermediate 2; subjecting the intermediate 2 to a Williamson
ether forming reaction with 1-fluoronaphthalene, so as to obtain a free alkali, i.e. (s)-N,N-dimethyl-3-(1-naphthyloxy)phenyl propyl amine; subjecting the free alkali to a salt forming reaction with
alcohol-
acyl chloride or a
chloride thereof, a
hydrochloric acid organic solution or
hydrochloric acid gas, thereby obtaining dapoxetine
hydrochloride. According to the method, the synthesis
route is low in production cost, the
reaction conditions are mild, all the materials are readily available, the raw materials are low in
toxicity, the reaction is simple in operation and high in safety, and the product is high in purity and yield and is
environmentally friendly, so that the method is applicable to industrial large-scale production.