The invention discloses an ink silk-screen process of a thick-copper white soldering resistant ink PCB. The silk-screen process comprises the following steps of S1, performing sand-blasting pre-processing on the thick-copper PCB to be silk-screened with soldering resistant ink, and performing plugging a conduction hole; S2, performing silk-screen printing of white soldering resistant ink, and allowing to stand; and S3, sequentially performing segmented pre-baking, alignment, exposure and developing, and completing ink silk-screen printing. According to the process, the white soldering resistant ink layer with a line shoulder thickness not lower than 7 micrometers can be completed on the thick-copper PCB by one-time silk-screen printing, the silk-screen process is improved, the silk-screen cost is reduced, and the problem that the ink layer is easy to crack during die punching is also prevented; moreover, by segmented pre-baking, the standing time after silk-screen is shorted, and the defect of white oil crack is also solved; and meanwhile, by controlling the energy of exposure and developing, the ink layer is maintained to be shiny, the developing is clear, and the defect that white oil crack is easily occurred after backflow welding or wave soldering at a client is effectively prevented.