Anti-heatstroke use of teprenone

A technology of teprenone and ability, which is applied in the field of anti-heat stroke application, to achieve the effect of improving the ability to resist heat damage, good economic benefits and social benefits
CN101164535AActive Publication Date: 2008-04-23INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
Publication Date
2008-04-23

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Abstract

The present invention relates to an application of teprenone (geranylgeranylacetone, GGA) for resisting heat apoplexy. Under the condition of peroral administration the teprenone can obviously delay heat apoplexy incidence of rat in heat environment and can prolong surviving time of the rate with heat apoplexy.
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Description

technical field

[0001] The invention relates to an anti-heat stroke application of teprenone (digeranylacetone). Under the condition of oral administration, teprenone can significantly delay the occurrence of heatstroke in rats in a hot environment and prolong the survival time of heatstroke rats. Background technique

[0002] Preventive measures for thermal environment damage and heatstroke are important topics in environmental medicine, military medicine, and aerospace medicine. So far, there is still no satisfactory drug for preventing heatstroke.

[0003] Teprenone (geranylgeranylacetone, GGA) is a relatively safe HSP70 inducer, which is commonly used in the treatment of ulcer disease. Teprenone can reduce the cytotoxic effect (Bai, 2002) and neuron injury (Kikuchi, 2002) that chemical substance causes by inducing HSP70; Vestibular cell injury (Takumida, 2005), epilepsy (Fujiki, 2003; 2004), cerebral infarction (Nagai, 2005; Yasuda, 2005; Nikaido, 2004) and so on have ...

Claims

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