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Method for preparing electrostatic spinning fiber film-coated vascular inner rack

An internal stent and electrospinning technology, applied in the field of micro-traumatic interventional medical products, can solve the problems of restenosis, affect the treatment effect, etc., and achieve the effect of preventing hyperplasia

Inactive Publication Date: 2008-04-30
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, restenosis still occurs after stent implantation, seriously affecting the treatment effect

Method used

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  • Method for preparing electrostatic spinning fiber film-coated vascular inner rack
  • Method for preparing electrostatic spinning fiber film-coated vascular inner rack

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0036] Prepare a trifluoroethanol solution of P(LLA-CL) with a concentration of 0.06 g / mL, fix the intravascular stent on the shaft, adjust the speed of the micro-injection pump to 1.5 mL / h, the voltage to 15.0 kV, and the receiving distance to 20.0 cm, the motor speed is 50 rpm, and after 30 minutes, the intravascular stent is covered with a P(LLA-CL) fibrous membrane with a thickness of about 0.10 mm.

example 2

[0038] The preparation P (LLA-CL) concentration is 0.06 g / ml, and the heparin concentration is 0.0006 g / ml mixed solution, the solvent used is THF / water complex solvent with a volume ratio of 10:1, and the intravascular stent is fixed on the rotating shaft, Adjust the rate of the micro-injection pump to 1.5 ml / hour, the voltage to 15.0 kV, the receiving distance to 20.0 cm, and the motor speed to 500 rpm. After 30 minutes, the intravascular stent is covered with a heparin-loaded layer with a thickness of about 0.10 mm. P(LLA-CL) fiber membrane.

example 3

[0040]Prepare a mixed solution with a concentration of PLLA of 0.06 g / ml and a concentration of rapamycin of 0.0012 g / ml. The solvent used is acetone, and the intravascular stent is fixed on the rotating shaft. 15.0 kV, the receiving distance is 20.0 cm, and the motor speed is 1000 rpm. After 30 minutes, the intravascular stent is covered with a P(LLA-CL) fiber membrane loaded with rapamycin with a thickness of about 0.10 mm.

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Abstract

The invention relates to a process for preparing an internal frame of a blood vessel with electrostatic fiber tectorial. The concrete procedure is that 1, preparing polymer solution or polymer solution with drugs or bioactive elements, 2 preparing to obtain nanometer / micrometer fiber, 3, forming a fiber film structure on the surface of the internal frame of the blood vessel. The shape of a fabric prepared by the invention imitates the shape of an epimatrix of a natural cell, thereby being beneficial for cells to sticki and breed, moreover, the drugs and active elements such as growth factor can be loaded in the nanometer fiber by an electro-spin to be released slowly, and the internal frame of the blood vessel with electrostatic fiber tectorial has good mechanical function, thereby satisfying the need of clinical releasing. In an implanting area, the invention can effectively support a lesion blood vessel to ensure the smoothness of the lesion blood vessel or can avoid dangers such as blood leakage due to angiomatosis in a diseased region. Simultaneously, the invention is capable of slowing releasing the drugs if necessary.

Description

technical field [0001] The invention belongs to the field of minimally traumatic interventional medical products, and in particular relates to a preparation method of an intravascular stent with an electrospun fiber coating. Background technique [0002] Atherosclerosis is one of the important causes of heart disease morbidity and death, which narrows the lumen of arteries and eventually blocks blood vessels. Insertion of intravascular stents is an important method for the treatment of cardiovascular diseases. Intravascular stents can support narrowed and occluded vessels to maintain smooth blood flow in the lumen. However, restenosis still occurs after stent placement, seriously affecting the therapeutic effect. At present, drug-coated stents are mainly used to inhibit the occurrence of restenosis, and there are also reports that drug-loaded polymer films are used to control restenosis. Aneurysm is a clinically very dangerous vascular disease. According to data, if the pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/04A61F2/82
Inventor 莫秀梅陈锋何创龙王红声
Owner DONGHUA UNIV
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