Atmospheric pressure liquid phase mass spectrometric analysis method and atmospheric pressure liquid phase mass spectrograph

A technology of atmospheric pressure and mass spectrometry, which is applied in the field of mass spectrometers, can solve the problems of exhaustion, high equipment cost, cumbersome pre-operation of liquid samples, etc., and achieve the effect of short operation time

Inactive Publication Date: 2008-05-07
NAT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0023] However, since this method was developed for the MALDI-MS analysis system, it is of course limited to operate under vacuum equipment, and a high-viscosity solvent such as glycerol is used to prepare the liquid sample, which leads to equipment cost Disadvantages such as high and cumbersome pre-work for liquid samples
[0024] Although a mass spectrometry method that can directly perform qualitative analysis on a liquid sample in an atmospheric pressure environment, is convenient to operate, saves time, and has high precision, it is of great help to various professional fields that need to be applied to chemical qualitative analysis, because this

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  • Atmospheric pressure liquid phase mass spectrometric analysis method and atmospheric pressure liquid phase mass spectrograph
  • Atmospheric pressure liquid phase mass spectrometric analysis method and atmospheric pressure liquid phase mass spectrograph
  • Atmospheric pressure liquid phase mass spectrometric analysis method and atmospheric pressure liquid phase mass spectrograph

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Embodiment 1

[0168] Figure 6 The shown atmospheric pressure liquid mass spectrometer of the present invention is used to perform mass spectrometric analysis on at least one liquid sample 4 . refer to Figures 4 to 6 , the liquid sample 4 includes a solution 41 and a matrix 42 mixed with the solution 41, the solution 41 has a solvent 411 and a plurality of analytes 412 to be desorbed and ionized, and the matrix 42 can assist The analyte 412 is desorbed; the atmospheric pressure liquid mass spectrometer includes a set of electrospray units 5 , a mass analyzer 6 , a detector 7 , a set of laser desorption units 8 and a set of carrying units 9 .

[0169] The laser desorption unit 8 includes an ultraviolet laser 82 capable of emitting a laser beam 81, a lens 83 arranged in the travel path of the laser beam 81 for gathering energy, and a lens 83 arranged in the travel path of the laser beam 81. And a mirror 84 for changing the traveling direction of the laser beam 81 . Basically, as long as t...

Embodiment 2

[0177] refer to Figure 6 , 7 , the structure and operation mode of Embodiment 2 are substantially the same as Embodiment 1, so the same point will not be repeated. The difference between the two is that the electrospray unit 5 of Embodiment 2 also includes a tube surrounding the nozzle 53. wall airflow supply mechanism 55, and toward as Figure 6 The mass analyzer 6 shown in provides a nitrogen stream 311 which is injected under high pressure to accelerate Figure 5 The liquid in the charged particles 511 volatilizes. Further, the temperature of the nitrogen flow 311 can be adjusted between room temperature and 325° C. according to the needs of the operator.

Embodiment 3

[0179] refer to Figure 6 , 8 , the structure and operation mode of embodiment 3 are also substantially the same as embodiment 1, and the same parts will not be repeated again. The difference between the two mainly lies in the electrospray unit 5; whether the nozzle 53 of embodiment 3 is made of metal, and Its electrospray unit 5 also has a three-way connection 56, and this three-way connection 56 has a nozzle end 531 far away from this nozzle 53 and is connected to the first end 561 of this nozzle 53, one for this electrospray medium 5 An incoming second end 562 and a grounded third end 563 .

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Abstract

The invention relates to a method of atmospheric liquid mass spectrometry analysis, which comprises the following steps: shooting a liquid sample with a laser beam, wherein, the liquid sample comprises medium and solution of specimen and solvent; the medium transferring energy to the specimen and assisting the specimen desorption; the desorbed specimen combining with a charged particle generated with an electrospray ionization unit to form a specimen ion; the specimen ion entering a mass analyzer and generating a mass spectrometry analysis result. Furthermore, if the solution is water solution, mass spectrometry analysis result also can be obtained through shooting the solution directly with an infrared laser beam without adding medium. The invention has the advantages that mass spectrometry analysis results with high reliability of one or more liquid samples are obtained quickly without complicated pretreatment. The invention also provides a mass spectrograph for performing the method, which comprises a bearing unit for laying the liquid sample, a mass analyzer, a detector, an electrospray ionization unit, and a laser desorption unit.

Description

【Technical field】 [0001] The invention relates to a mass spectrometry analysis method, in particular to a method capable of directly performing mass spectrometry analysis on a test substance in a liquid sample under an atmospheric pressure environment. The present invention also relates to a mass spectrometer for implementing the above mass spectrometry method. 【Background technique】 [0002] With the help of mass spectrometry technology, people can know the molecular weight of the analyte in a sample, and then cooperate with further comparison to confirm the true identity of the analyte. Because of its advantages of easy operation and quick test results, it has become a widely used identification tool in various fields. [0003] A general mass spectrometer mainly includes three major components: an ionization device, a mass analyzer, and a detector. Each analyte in the sample is charged by the ionization device, so it is ionized to form an analyte ion, and then the analyt...

Claims

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Application Information

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IPC IPC(8): G01N30/72G01N30/00H01J49/26
Inventor 谢建台袁景辉
Owner NAT SUN YAT SEN UNIV
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